dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SUV39H1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2000362 STOMACH c.1133G>A p.R378H COSMIC PASSENGER/OTHER Probably Damaging 2 587222 LARGE INTESTINE c.1138G>A p.D380N COSMIC PASSENGER/OTHER Possibly Damaging 3 587234 LARGE INTESTINE c.657C>G p.I219M COSMIC CANCER Probably Damaging 4 587248 LARGE INTESTINE c.657C>G p.I219M COSMIC CANCER Probably Damaging 5 ESO-0061 OESOPHAGUS c.703C>T p.R235C COSMIC CANCER Probably Damaging 6 H1155 LUNG c.85T>C p.S29P COSMIC PASSENGER/OTHER Possibly Damaging 7 HCC136T LIVER c.1065C>T p.I355I COSMIC NP NP 8 HN_62469 UPPER AERODIGESTIVE TRACT c.1114G>A p.V372M COSMIC PASSENGER/OTHER Benign 9 LUAD-B01970 LUNG c.742T>G p.F248V COSMIC PASSENGER/OTHER Probably Damaging 10 LUAD-NYU282 LUNG c.1153C>G p.L385V COSMIC PASSENGER/OTHER Benign 11 PA285 PANCREAS c.593C>T p.A198V COSMIC CANCER Benign 12 TCGA-18-3414-01 LUNG c.856C>T p.R286W COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-18-4083-01 LUNG c.614A>G p.Y205C COSMIC CANCER Probably Damaging 14 TCGA-49-4514-01 LUNG c.649C>A p.L217M COSMIC CANCER Benign 15 TCGA-50-6594-01 LUNG c.354G>A p.L118L COSMIC NP NP 16 TCGA-A6-2677-01 LARGE INTESTINE c.837C>T p.T279T COSMIC NP NP 17 TCGA-A6-5661-01 LARGE INTESTINE c.1042G>A p.A348T COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-A6-5665-01 LARGE INTESTINE c.588delG p.A198fs*140 COSMIC NP NP 19 TCGA-AA-3516-01 LARGE INTESTINE c.909C>T p.Y303Y COSMIC NP NP 20 TCGA-AA-3518-01 LARGE INTESTINE c.776G>A p.R259H COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AA-3525-01 LARGE INTESTINE c.996G>C p.V332V COSMIC NP NP 22 TCGA-AP-A059-01 ENDOMETRIUM c.159G>T p.K53N COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-AP-A059-01 ENDOMETRIUM c.171G>T p.Q57H COSMIC PASSENGER/OTHER Possibly Damaging 24 TCGA-AP-A059-01 ENDOMETRIUM c.21C>A p.G7G COSMIC NP NP 25 TCGA-AP-A059-01 ENDOMETRIUM c.273G>A p.K91K COSMIC NP NP 26 TCGA-AU-6004-01 LARGE INTESTINE c.634C>T p.R212W COSMIC CANCER Probably Damaging 27 TCGA-B0-5120-01 KIDNEY c.135C>A p.V45V COSMIC NP NP 28 TCGA-B5-A0JY-01 ENDOMETRIUM c.1183C>T p.R395W COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-B5-A1MU-01 ENDOMETRIUM c.771C>T p.G257G COSMIC NP NP 30 TCGA-BG-A0VZ-01 ENDOMETRIUM c.69C>T p.C23C COSMIC NP NP 31 TCGA-D1-A103-01 ENDOMETRIUM c.864G>T p.Q288H COSMIC PASSENGER/OTHER Benign 32 TCGA-D1-A16F-01 ENDOMETRIUM c.706G>A p.V236M COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-D1-A16X-01 ENDOMETRIUM c.882C>T p.G294G COSMIC NP NP 34 TCGA-D5-6534-01 LARGE INTESTINE c.57G>A p.L19L COSMIC NP NP 35 TCGA-EY-A1GS-01 ENDOMETRIUM c.448G>A p.E150K COSMIC PASSENGER/OTHER Benign 36 WA16 PROSTATE c.875G>A p.R292H COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 121 K Ubiquitylation 2 138 K Ubiquitylation 3 266 K Acetylation 4 391 S Phosphorylation 5 391 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SUV39H1 SUV39H1 SUV39H1 ENSP00000337976 O43463 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O43463 SUV39H1 ENSP00000337976 SUV39H1 O43463 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SUV39H1 ENSP00000337976 300254 O43463 PA36264
