dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SUV39H2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 134427 LUNG c.148A>T p.I50L COSMIC NP NP 2 587284 LARGE INTESTINE c.92A>G p.Q31R COSMIC NP NP 3 587350 LARGE INTESTINE c.878G>A p.R293Q COSMIC PASSENGER/OTHER Probably Damaging 4 587376 LARGE INTESTINE c.445C>A p.L149I COSMIC NP NP 5 HCC2157 BREAST c.967G>C p.D323H COSMIC NP NP 6 HCC73T LIVER c.843T>C p.N281N COSMIC NP NP 7 HCC8T LIVER c.231G>A p.L77L COSMIC NP NP 8 HX14T LIVER c.231G>A p.L77L COSMIC NP NP 9 LUAD-CHTN-3090415 LUNG c.691G>A p.E231K COSMIC NP NP 10 TCGA-05-4427-01 LUNG c.438T>C p.A146A COSMIC NP NP 11 TCGA-24-1466-01 OVARY c.313C>G p.P105A COSMIC NP NP 12 TCGA-39-5030-01 LUNG c.507C>A p.C169* COSMIC NP NP 13 TCGA-63-5128-01 LUNG c.512C>G p.S171* COSMIC NP NP 14 TCGA-64-5778-01 LUNG c.659A>C p.Y220S COSMIC NP NP 15 TCGA-67-3771-01 LUNG c.363C>T p.I121I COSMIC NP NP 16 TCGA-78-7154-01 LUNG c.275G>A p.G92E COSMIC NP NP 17 TCGA-78-7160-01 LUNG c.404A>G p.D135G COSMIC NP NP 18 TCGA-A3-3374-01 KIDNEY c.459T>A p.N153K COSMIC NP NP 19 TCGA-AA-3710-01 LARGE INTESTINE c.827A>G p.N276S COSMIC NP NP 20 TCGA-AA-3977-01 LARGE INTESTINE c.638G>T p.R213I COSMIC NP NP 21 TCGA-AG-3609-01 LARGE INTESTINE c.878G>A p.R293Q COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AP-A054-01 ENDOMETRIUM c.423T>C p.C141C COSMIC NP NP 23 TCGA-AP-A056-01 ENDOMETRIUM c.861C>T p.L287L COSMIC NP NP 24 TCGA-AX-A05Z-01 ENDOMETRIUM c.260G>T p.R87I COSMIC NP NP 25 TCGA-AX-A05Z-01 ENDOMETRIUM c.587G>A p.R196Q COSMIC NP NP 26 TCGA-AZ-4315-01 LARGE INTESTINE c.776C>T p.A259V COSMIC NP NP 27 TCGA-AZ-6599-01 LARGE INTESTINE c.313C>T p.P105S COSMIC NP NP 28 TCGA-AZ-6608-01 LARGE INTESTINE c.968A>G p.D323G COSMIC NP Probably Damaging 29 TCGA-B5-A0K6-01 ENDOMETRIUM c.563C>T p.T188I COSMIC PASSENGER/OTHER Benign 30 TCGA-BG-A0MQ-01 ENDOMETRIUM c.572C>T p.S191L COSMIC NP NP 31 TCGA-CA-6717-01 LARGE INTESTINE c.641T>C p.M214T COSMIC NP NP 32 TCGA-CJ-5682-01 KIDNEY c.712G>A p.D238N COSMIC CANCER Benign 33 TCGA-CJ-5682-01 KIDNEY c.714C>A p.D238E COSMIC CANCER Benign 34 TCGA-CM-5861-01 LARGE INTESTINE c.339C>T p.N113N COSMIC NP NP 35 TCGA-CZ-5461-01 KIDNEY c.809A>G p.N270S COSMIC NP NP 36 TCGA-D1-A103-01 ENDOMETRIUM c.587G>A p.R196Q COSMIC NP NP 37 TCGA-D1-A16O-01 ENDOMETRIUM c.931G>T p.D311Y COSMIC NP NP 38 TCGA-FU-A23L-01 CERVIX c.968A>T p.D323V COSMIC NP NP 39 TCGA-G2-A2EF-01 URINARY TRACT c.630G>A p.K210K COSMIC NP NP 40 YUSEL SKIN c.29G>A p.G10E COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 2 A Acetylation 2 248 T Phosphorylation 3 303 T Phosphorylation 4 310 Y Phosphorylation 5 316 T Phosphorylation 6 381 S Phosphorylation 7 381 S Phosphorylation 8 382 S Phosphorylation 9 382 S Phosphorylation 10 384 S Phosphorylation 11 384 S Phosphorylation 12 388 S Phosphorylation 13 388 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SUV39H2 SUV39H2 SUV39H2 ENSP00000319208 Q9H5I1 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H5I1 SUV39H2 ENSP00000319208 SUV39H2 Q9H5I1 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SUV39H2 ENSP00000319208 606503 Q9H5I1 PA134868807
