dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SUV420H1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334192 LUNG c.1891C>G p.P631A COSMIC PASSENGER/OTHER Benign 2 587284 LARGE INTESTINE c.40G>T p.G14C COSMIC PASSENGER/OTHER Probably Damaging 3 587376 LARGE INTESTINE c.1836G>T p.K612N COSMIC PASSENGER/OTHER Probably Damaging 4 587376 LARGE INTESTINE c.2326A>G p.K776E COSMIC PASSENGER/OTHER Probably Damaging 5 587376 LARGE INTESTINE c.355T>G p.F119V COSMIC PASSENGER/OTHER Benign 6 587376 LARGE INTESTINE c.560G>A p.R187Q COSMIC PASSENGER/OTHER Probably Damaging 7 8013142 PANCREAS c.2418T>C p.L806L COSMIC NP NP 8 8015870 PANCREAS c.2418T>C p.L806L COSMIC NP NP 9 CLL012 HAEMATOPOIETIC AND LYMPHOID TISSUE c.947A>G p.N316S COSMIC PASSENGER/OTHER Probably Damaging 10 H1672 LUNG c.1891C>G p.P631A COSMIC PASSENGER/OTHER Benign 11 HCC2998 LARGE INTESTINE c.1450C>A p.L484M COSMIC PASSENGER/OTHER Probably Damaging 12 HN_62624 UPPER AERODIGESTIVE TRACT c.489A>G p.A163A COSMIC NP NP 13 HN_62810 UPPER AERODIGESTIVE TRACT c.2574G>C p.L858F COSMIC PASSENGER/OTHER Probably Damaging 14 ICGC_0030 PANCREAS c.2418T>C p.L806L COSMIC NP NP 15 ICGC_0057 PANCREAS c.2418T>C p.L806L COSMIC NP NP 16 KM12 LARGE INTESTINE c.2095C>T p.R699* COSMIC NP NP 17 LC_C25 LUNG c.2087_2089delAGA p.K697delK COSMIC NP NP 18 LC_C25 LUNG c.2091_2093delGAG p.R699delR COSMIC NP NP 19 LC_C6 LUNG c.713A>T p.E238V COSMIC PASSENGER/OTHER Probably Damaging 20 LC_S11 LUNG c.706G>T p.E236* COSMIC NP NP 21 LC_S19 LUNG c.268G>A p.D90N COSMIC PASSENGER/OTHER Probably Damaging 22 LUAD-B01145 LUNG c.2272T>C p.Y758H COSMIC PASSENGER/OTHER Probably Damaging 23 LUAD-F00018 LUNG c.2087_2088insA p.K697fs*8 COSMIC NP NP 24 LUAD-S00488 LUNG c.744C>T p.N248N COSMIC NP NP 25 LUAD_E00522 LUNG c.2069G>C p.R690T COSMIC PASSENGER/OTHER Probably Damaging 26 ME009T SKIN c.191G>A p.S64N COSMIC PASSENGER/OTHER Probably Damaging 27 ME018T NS c.271C>T p.P91S COSMIC PASSENGER/OTHER Probably Damaging 28 PACA50 PANCREAS c.2333A>G p.K778R COSMIC PASSENGER/OTHER Probably Damaging 29 PD2152a KIDNEY c.798T>C p.G266G COSMIC NP NP 30 PR-00-1165 PROSTATE c.310G>A p.A104T COSMIC PASSENGER/OTHER Benign 31 PR-01-2554 PROSTATE c.2369C>T p.S790F COSMIC PASSENGER/OTHER Possibly Damaging 32 SA090 BREAST c.1234A>T p.R412W COSMIC PASSENGER/OTHER Probably Damaging 33 SA106 BREAST c.2627G>C p.R876T COSMIC PASSENGER/OTHER Probably Damaging 34 SK-MEL-2 SKIN c.841delT p.F281fs*11 COSMIC NP NP 35 TCGA-05-4397-01 LUNG c.848C>T p.S283L COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-05-4432-01 LUNG c.1657G>A p.D553N COSMIC PASSENGER/OTHER Possibly Damaging 37 TCGA-05-4432-01 LUNG c.1987G>T p.V663L COSMIC PASSENGER/OTHER Benign 38 TCGA-13-0760-01 OVARY c.2283G>T p.K761N COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-18-3409-01 LUNG c.2551C>T p.P851S COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-21-1071-01 LUNG c.1918G>C p.D640H COSMIC PASSENGER/OTHER Benign 41 TCGA-22-5472-01 LUNG c.2618C>A p.S873* COSMIC NP NP 42 TCGA-23-1118-01 OVARY c.2008C>A p.P670T COSMIC PASSENGER/OTHER Benign 43 TCGA-37-4133-01 LUNG c.1706C>A p.T569K COSMIC PASSENGER/OTHER Benign 44 TCGA-50-5946-01 LUNG c.1655C>G p.S552C COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-50-5946-01 LUNG c.1747C>G p.P583A COSMIC PASSENGER/OTHER Benign 46 TCGA-50-5946-01 LUNG c.2337C>T p.I779I COSMIC NP NP 47 TCGA-50-5946-02 LUNG c.1655C>G p.S552C COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-50-5946-02 LUNG c.1747C>G p.P583A COSMIC PASSENGER/OTHER Benign 49 TCGA-50-5946-02 LUNG c.2337C>T p.I779I COSMIC NP NP 50 TCGA-55-7726-01 LUNG c.2032G>C p.V678L COSMIC PASSENGER/OTHER Possibly Damaging 51 TCGA-55-7911-01 LUNG c.257G>C p.S86T COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-66-2785-01 LUNG c.1120C>G p.Q374E COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-66-2785-01 LUNG c.181G>C p.E61Q COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-73-4666-01 LUNG c.581G>C p.G194A COSMIC PASSENGER/OTHER Probably Damaging 55 TCGA-78-7155-01 LUNG c.1277C>T p.S426L COSMIC PASSENGER/OTHER Probably Damaging 56 TCGA-78-7155-01 LUNG c.1280C>G p.S427C COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-78-7155-01 LUNG c.1747C>A p.P583T COSMIC PASSENGER/OTHER Benign 58 TCGA-78-7155-01 LUNG c.2027C>T p.S676L COSMIC PASSENGER/OTHER Benign 59 TCGA-78-7155-01 LUNG c.2259C>T p.N753N COSMIC NP NP 60 TCGA-78-7155-01 LUNG c.2386C>T p.H796Y COSMIC PASSENGER/OTHER Possibly Damaging 61 TCGA-78-7155-01 LUNG c.2416C>G p.L806V COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-A2-A0D2-01 BREAST c.1673C>A p.P558Q COSMIC PASSENGER/OTHER Probably Damaging 63 TCGA-A5-A0G9-01 ENDOMETRIUM c.83A>T p.N28I COSMIC PASSENGER/OTHER Possibly Damaging 64 TCGA-A6-2676-01 LARGE INTESTINE c.220G>A p.A74T COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-A6-6780-01 LARGE INTESTINE c.958G>A p.E320K COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-A6-6781-01 LARGE INTESTINE c.1707G>A p.T569T COSMIC NP NP 67 TCGA-A6-6781-01 LARGE INTESTINE c.2158_2159delCT p.L720fs*2 COSMIC NP NP 68 TCGA-A8-A0A7-01 BREAST c.764C>T p.S255F COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-AA-3489-01 LARGE INTESTINE c.914G>A p.C305Y COSMIC PASSENGER/OTHER Probably Damaging 70 TCGA-AA-3663-01 LARGE INTESTINE c.792G>A p.W264* COSMIC NP NP 71 TCGA-AA-3666-01 LARGE INTESTINE c.1850G>A p.G617E COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-AA-A00E-01 LARGE INTESTINE c.1721A>G p.D574G COSMIC PASSENGER/OTHER Benign 73 TCGA-AA-A010-01 LARGE INTESTINE c.1461T>G p.N487K COSMIC PASSENGER/OTHER Possibly Damaging 74 TCGA-AA-A010-01 LARGE INTESTINE c.909T>G p.I303M COSMIC PASSENGER/OTHER Probably Damaging 75 TCGA-AA-A01R-01 LARGE INTESTINE c.2259C>T p.N753N COSMIC NP NP 76 TCGA-AD-6548-01 LARGE INTESTINE c.2283G>A p.K761K COSMIC NP NP 77 TCGA-AG-A002-01 LARGE INTESTINE c.2006C>T p.A669V COSMIC PASSENGER/OTHER Benign 78 TCGA-AG-A002-01 LARGE INTESTINE c.47G>T p.R16I COSMIC PASSENGER/OTHER Probably Damaging 79 TCGA-AG-A002-01 LARGE INTESTINE c.745G>A p.D249N COSMIC PASSENGER/OTHER Benign 80 TCGA-AO-A1KS-01 BREAST c.577A>T p.S193C COSMIC PASSENGER/OTHER Probably Damaging 81 TCGA-AP-A051-01 ENDOMETRIUM c.194G>A p.R65H COSMIC PASSENGER/OTHER Probably Damaging 82 TCGA-AP-A056-01 ENDOMETRIUM c.772A>G p.K258E COSMIC PASSENGER/OTHER Possibly Damaging 83 TCGA-AP-A059-01 ENDOMETRIUM c.2347C>T p.R783* COSMIC NP NP 84 TCGA-AP-A0LG-01 ENDOMETRIUM c.714G>A p.E238E COSMIC NP NP 85 TCGA-AP-A0LM-01 ENDOMETRIUM c.193C>T p.R65C COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-AP-A0LM-01 ENDOMETRIUM c.402G>T p.Q134H COSMIC PASSENGER/OTHER Possibly Damaging 87 TCGA-AX-A05Z-01 ENDOMETRIUM c.173C>T p.S58L COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-AX-A05Z-01 ENDOMETRIUM c.659G>A p.R220Q COSMIC PASSENGER/OTHER Benign 89 TCGA-AX-A0J0-01 ENDOMETRIUM c.659G>A p.R220Q COSMIC PASSENGER/OTHER Benign 90 TCGA-B0-5094-01 KIDNEY c.1465C>T p.P489S COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-B2-4099-01 KIDNEY c.593T>G p.L198W COSMIC PASSENGER/OTHER Probably Damaging 92 TCGA-B5-A11N-01 ENDOMETRIUM c.24G>T p.K8N COSMIC PASSENGER/OTHER Probably Damaging 93 TCGA-BH-A209-01 BREAST c.2482G>A p.D828N COSMIC PASSENGER/OTHER Benign 94 TCGA-BP-4994-01 KIDNEY c.2231G>T p.S744I COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-BS-A0TJ-01 ENDOMETRIUM c.2259C>T p.N753N COSMIC NP NP 96 TCGA-BS-A0UF-01 ENDOMETRIUM c.676T>G p.L226V COSMIC PASSENGER/OTHER Probably Damaging 97 TCGA-BS-A0UF-01 ENDOMETRIUM c.806C>T p.A269V COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-BS-A0UM-01 ENDOMETRIUM c.402G>T p.Q134H COSMIC PASSENGER/OTHER Possibly Damaging 99 TCGA-BS-A0UV-01 ENDOMETRIUM c.1410C>T p.L470L COSMIC NP NP 100 TCGA-BS-A0UV-01 ENDOMETRIUM c.381T>G p.F127L COSMIC PASSENGER/OTHER Benign 101 TCGA-BT-A3PH-01 URINARY TRACT c.45G>C p.R15S COSMIC PASSENGER/OTHER Probably Damaging 102 TCGA-CA-6717-01 LARGE INTESTINE c.1044A>C p.K348N COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-CA-6717-01 LARGE INTESTINE c.911C>A p.S304Y COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-CA-6718-01 LARGE INTESTINE c.904G>T p.E302* COSMIC NP NP 105 TCGA-CM-5341-01 LARGE INTESTINE c.2010T>C p.P670P COSMIC NP NP 106 TCGA-CM-5861-01 LARGE INTESTINE c.798T>C p.G266G COSMIC NP NP 107 TCGA-CM-6162-01 LARGE INTESTINE c.2009C>T p.P670L COSMIC PASSENGER/OTHER Benign 108 TCGA-CM-6678-01 LARGE INTESTINE c.2010T>C p.P670P COSMIC NP NP 109 TCGA-CU-A0YN-01 URINARY TRACT c.497A>G p.Y166C COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-D1-A15X-01 ENDOMETRIUM c.1532G>T p.R511I COSMIC PASSENGER/OTHER Probably Damaging 111 TCGA-D1-A17Q-01 ENDOMETRIUM c.1615C>T p.R539W COSMIC PASSENGER/OTHER Probably Damaging 112 TCGA-D1-A17Q-01 ENDOMETRIUM c.1844G>A p.R615Q COSMIC PASSENGER/OTHER Probably Damaging 113 TCGA-D5-6536-01 LARGE INTESTINE c.2008C>A p.P670T COSMIC PASSENGER/OTHER Benign 114 TCGA-D5-6540-01 LARGE INTESTINE c.2010T>C p.P670P COSMIC NP NP 115 TCGA-D8-A1JK-01 BREAST c.309C>T p.S103S COSMIC NP NP 116 TCGA-DC-6157-01 LARGE INTESTINE c.194G>A p.R65H COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-DK-A1A5-01 URINARY TRACT c.1190C>A p.S397Y COSMIC PASSENGER/OTHER Probably Damaging 118 TCGA-DK-A1A6-01 URINARY TRACT c.1004G>C p.R335T COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-E9-A1RG-01 BREAST c.1922C>T p.A641V COSMIC PASSENGER/OTHER Benign 120 TCGA-FD-A3B3-01 URINARY TRACT c.1543A>G p.R515G COSMIC PASSENGER/OTHER Probably Damaging 121 TCGA-FD-A3B6-01 URINARY TRACT c.47G>C p.R16T COSMIC PASSENGER/OTHER Probably Damaging 122 WA18 PROSTATE c.2395_2396delGG p.C801fs*3 COSMIC NP NP 123 YULAN SKIN c.2558C>T p.P853L COSMIC PASSENGER/OTHER Probably Damaging 124 cSCCP1 SKIN c.1907C>T p.P636L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 107 S Phosphorylation 2 307 Y Phosphorylation 3 322 Y Phosphorylation 4 726 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SUV420H1 SUV420H1 SUV420H1 ENSP00000305899 Q4FZB7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q4FZB7 SUV420H1 ENSP00000305899 SUV420H1 Q4FZB7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SUV420H1 ENSP00000305899 610881 Q4FZB7 PA134958369
