dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SUV420H2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587290 LARGE INTESTINE c.206C>T p.T69M COSMIC NP Probably Damaging 2 587336 LARGE INTESTINE c.284G>A p.R95H COSMIC PASSENGER/OTHER Benign 3 587350 LARGE INTESTINE c.1192C>A p.L398M COSMIC CANCER Probably Damaging 4 587350 LARGE INTESTINE c.1231C>A p.P411T COSMIC PASSENGER/OTHER Benign 5 90468 HAEMATOPOIETIC AND LYMPHOID TISSUE c.642A>G p.T214T COSMIC NP NP 6 ESO-717 OESOPHAGUS c.506G>A p.R169Q COSMIC PASSENGER/OTHER Benign 7 HCC134T LIVER c.129G>T p.R43R COSMIC NP NP 8 HCC57T LIVER c.133C>A p.Q45K COSMIC NP Benign 9 HCT-15 LARGE INTESTINE c.56C>A p.T19N COSMIC NP Probably Damaging 10 LUAD-NYU796 LUNG c.347T>G p.M116R COSMIC PASSENGER/OTHER Benign 11 LUAD-S01302 LUNG c.881G>C p.R294P COSMIC PASSENGER/OTHER Benign 12 PA254 PANCREAS c.311_312delGT p.S104fs*29 COSMIC NP NP 13 RK064_C01 LIVER c.356A>G p.N119S COSMIC PASSENGER/OTHER Benign 14 TCGA-22-4599-01 LUNG c.57C>A p.T19T COSMIC NP NP 15 TCGA-A6-5665-01 LARGE INTESTINE c.106G>A p.V36I COSMIC NP Possibly Damaging 16 TCGA-AU-6004-01 LARGE INTESTINE c.651C>T p.Y217Y COSMIC NP NP 17 TCGA-AX-A0J1-01 ENDOMETRIUM c.9C>T p.P3P COSMIC NP NP 18 TCGA-BS-A0UF-01 ENDOMETRIUM c.30A>G p.E10E COSMIC NP NP 19 TCGA-D1-A0ZR-01 ENDOMETRIUM c.356A>G p.N119S COSMIC PASSENGER/OTHER Benign 20 TCGA-D1-A103-01 ENDOMETRIUM c.612C>T p.L204L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score. -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 122 K Ubiquitylation 2 416 T Phosphorylation 3 422 T Phosphorylation 4 449 S Phosphorylation 5 452 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SUV420H2 SUV420H2 SUV420H2 ENSP00000255613 Q86Y97 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q86Y97 SUV420H2 ENSP00000255613 SUV420H2 Q86Y97 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SUV420H2 ENSP00000255613 613198 Q86Y97
