dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: TET1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.1768C>T p.R590* CCLE NP NP 2 BL41 HAEMATOPOIETIC AND LYMPHOID TISSUE c.5509G>T p.A1837S CCLE PASSENGER/OTHER Benign 3 CAKI1 KIDNEY c.4467_4467delA p.L1489fs CCLE NP NP 4 CL34 LARGE INTESTINE c.4780C>T p.P1594S CCLE PASSENGER/OTHER Benign 5 CMLT1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.6127C>T p.R2043C CCLE PASSENGER/OTHER Probably Damaging 6 COLO818 SKIN c.4055C>G p.T1352S CCLE PASSENGER/OTHER Benign 7 CW2 LARGE INTESTINE c.242G>A p.R81H CCLE PASSENGER/OTHER Probably Damaging 8 DMS53 LUNG c.1774_1775GG>TT p.G592L CCLE PASSENGER/OTHER Probably Damaging 9 DMS53 LUNG c.4775G>T p.R1592I CCLE PASSENGER/OTHER Possibly Damaging 10 EFO27 OVARY c.986T>G p.F329C CCLE PASSENGER/OTHER Possibly Damaging 11 EN ENDOMETRIUM c.344T>C p.L115P CCLE PASSENGER/OTHER Probably Damaging 12 EN ENDOMETRIUM c.66_67insA p.K22fs CCLE NP NP 13 GCT SOFT TISSUE c.3386C>T p.S1129L CCLE PASSENGER/OTHER Benign 14 GP2D LARGE INTESTINE c.986T>C p.F329S CCLE PASSENGER/OTHER Benign 15 GSS STOMACH c.4182T>A p.N1394K CCLE PASSENGER/OTHER Benign 16 HCC1143 BREAST c.2617G>A p.V873I CCLE PASSENGER/OTHER Possibly Damaging 17 HCT15 LARGE INTESTINE c.1336C>T p.P446S CCLE PASSENGER/OTHER Benign 18 HCT15 LARGE INTESTINE c.242G>A p.R81H CCLE PASSENGER/OTHER Probably Damaging 19 HCT15 LARGE INTESTINE c.530A>C p.N177T CCLE PASSENGER/OTHER Benign 20 HEC108 ENDOMETRIUM c.1348C>G p.P450A CCLE PASSENGER/OTHER Probably Damaging 21 HEC108 ENDOMETRIUM c.3646T>G p.S1216A CCLE PASSENGER/OTHER Benign 22 HEC108 ENDOMETRIUM c.5376C>A p.N1792K CCLE PASSENGER/OTHER Benign 23 HEC1A ENDOMETRIUM c.1525C>T p.P509S CCLE PASSENGER/OTHER Probably Damaging 24 HEC1B ENDOMETRIUM c.1525C>T p.P509S CCLE PASSENGER/OTHER Probably Damaging 25 HEC251 ENDOMETRIUM c.4181A>C p.N1394T CCLE PASSENGER/OTHER Benign 26 HEC251 ENDOMETRIUM c.4206C>A p.F1402L CCLE PASSENGER/OTHER Benign 27 HEC251 ENDOMETRIUM c.4235C>T p.S1412F CCLE PASSENGER/OTHER Probably Damaging 28 HEC251 ENDOMETRIUM c.4864C>T p.R1622* CCLE NP NP 29 HRT18 LARGE INTESTINE c.1336C>T p.P446S CCLE PASSENGER/OTHER Benign 30 HRT18 LARGE INTESTINE c.242G>A p.R81H CCLE PASSENGER/OTHER Probably Damaging 31 HRT18 LARGE INTESTINE c.4318C>A p.L1440I CCLE PASSENGER/OTHER Probably Damaging 32 HRT18 LARGE INTESTINE c.530A>C p.N177T CCLE PASSENGER/OTHER Benign 33 HT115 LARGE INTESTINE c.1516A>C p.S506R CCLE PASSENGER/OTHER Benign 34 HT115 LARGE INTESTINE c.2003A>C p.K668T CCLE PASSENGER/OTHER Benign 35 HT115 LARGE INTESTINE c.3429G>T p.K1143N CCLE PASSENGER/OTHER Probably Damaging 36 HT55 LARGE INTESTINE c.558A>T p.Q186H CCLE PASSENGER/OTHER Probably Damaging 37 JHUEM7 ENDOMETRIUM c.4206C>A p.F1402L CCLE PASSENGER/OTHER Benign 38 KG1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1534A>G p.T512A CCLE PASSENGER/OTHER Benign 39 KNS62 LUNG c.3214C>T p.Q1072* CCLE NP NP 40 KYM1 SOFT TISSUE c.879A>T p.E293D CCLE PASSENGER/OTHER Benign 41 L428 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3596G>A p.G1199E CCLE PASSENGER/OTHER Probably Damaging 42 LC1SQSF LUNG c.1153C>T p.H385Y CCLE PASSENGER/OTHER Benign 43 LOVO LARGE INTESTINE c.2765G>T p.R922I CCLE PASSENGER/OTHER Benign 44 LS411N LARGE INTESTINE c.4340C>T p.A1447V CCLE PASSENGER/OTHER Probably Damaging 45 MDAMB453 BREAST c.5794G>A p.E1932K CCLE PASSENGER/OTHER Probably Damaging 46 MDAMB453 BREAST c.5950G>A p.E1984K CCLE PASSENGER/OTHER Benign 47 MDAPCA2B PROSTATE c.1334C>G p.A445G CCLE PASSENGER/OTHER Benign 48 MEWO SKIN c.1510C>T p.H504Y CCLE PASSENGER/OTHER Possibly Damaging 49 MEWO SKIN c.2870C>T p.P957L CCLE PASSENGER/OTHER Benign 50 MHHCALL2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.986T>G p.F329C CCLE PASSENGER/OTHER Possibly Damaging 51 NCIH1184 LUNG c.4411T>A p.Y1471N CCLE PASSENGER/OTHER Probably Damaging 52 NCIH1623 LUNG c.1792C>A p.Q598K CCLE PASSENGER/OTHER Probably Damaging 53 NCIH1781 LUNG c.6223A>T p.N2075Y CCLE PASSENGER/OTHER Possibly Damaging 54 NCIH1838 LUNG c.49G>A p.D17N CCLE PASSENGER/OTHER Benign 55 NCIH2110 LUNG c.4736G>A p.C1579Y CCLE PASSENGER/OTHER Possibly Damaging 56 NCIH2342 LUNG c.5348G>A p.R1783Q CCLE PASSENGER/OTHER Probably Damaging 57 NCIH510 LUNG c.5300C>T p.A1767V CCLE PASSENGER/OTHER Benign 58 OC316 OVARY c.4914G>T p.Q1638H CCLE PASSENGER/OTHER Probably Damaging 59 OCIAML3 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2482C>T p.P828S CCLE PASSENGER/OTHER Possibly Damaging 60 RERFGC1B STOMACH c.793A>G p.N265D CCLE PASSENGER/OTHER Possibly Damaging 61 RKO LARGE INTESTINE c.4826_4826delA p.E1609fs CCLE NP NP 62 SKMEL2 SKIN c.4412A>G p.Y1471C CCLE PASSENGER/OTHER Probably Damaging 63 SKUT1 SOFT TISSUE c.58_58delA p.K20fs CCLE NP NP 64 SNU1040 LARGE INTESTINE c.3692A>G p.Q1231R CCLE PASSENGER/OTHER Benign 65 SNU1040 LARGE INTESTINE c.5614T>G p.F1872V CCLE PASSENGER/OTHER Benign 66 SNU175 LARGE INTESTINE c.5222G>A p.R1741H CCLE PASSENGER/OTHER Possibly Damaging 67 SNU46 UPPER AERODIGESTIVE TRACT c.32G>C p.R11T CCLE PASSENGER/OTHER Benign 68 SNU475 LIVER c.1981A>C p.N661H CCLE PASSENGER/OTHER Benign 69 SNU81 LARGE INTESTINE c.5132A>G p.Y1711C CCLE PASSENGER/OTHER Probably Damaging 70 SNU81 LARGE INTESTINE c.6386C>T p.A2129V CCLE PASSENGER/OTHER Probably Damaging 71 SNU81 LARGE INTESTINE c.973T>C p.S325P CCLE PASSENGER/OTHER Probably Damaging 72 SNU886 LIVER c.1348C>G p.P450A CCLE PASSENGER/OTHER Probably Damaging 73 SW480 LARGE INTESTINE c.719C>A p.P240Q CCLE PASSENGER/OTHER Benign 74 SW48 LARGE INTESTINE c.3319C>T p.L1107F CCLE PASSENGER/OTHER Probably Damaging 75 TUHR10TKB KIDNEY c.6382G>A p.V2128I CCLE PASSENGER/OTHER Probably Damaging 76 104104 BREAST c.3927T>A p.C1309* COSMIC NP NP 77 111995 PROSTATE c.985T>G p.F329V COSMIC PASSENGER/OTHER Benign 78 112295 LUNG c.5656G>C p.G1886R COSMIC PASSENGER/OTHER Possibly Damaging 79 266 UPPER AERODIGESTIVE TRACT c.919C>A p.P307T COSMIC PASSENGER/OTHER Possibly Damaging 80 94699 LUNG c.5143G>A p.D1715N COSMIC PASSENGER/OTHER Benign 81 HN_62506 UPPER AERODIGESTIVE TRACT c.5347C>A p.R1783R COSMIC NP NP 82 HN_62686 UPPER AERODIGESTIVE TRACT c.5537C>T p.P1846L COSMIC PASSENGER/OTHER Possibly Damaging 83 TCGA-13-0804-01 OVARY c.3769G>T p.V1257F COSMIC PASSENGER/OTHER Benign 84 TCGA-13-0884-01 OVARY c.3621T>G p.P1207P COSMIC NP NP 85 TCGA-13-0899-01 OVARY c.6067G>A p.A2023T COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-24-0966-01 OVARY c.5118T>A p.H1706Q COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-24-1545-01 OVARY c.4513C>T p.R1505C COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-AA-3864-01 LARGE INTESTINE c.4325C>T p.A1442V COSMIC PASSENGER/OTHER Probably Damaging 89 TCGA-AA-A00J-01 LARGE INTESTINE c.5650C>T p.P1884S COSMIC PASSENGER/OTHER Benign 90 TCGA-AA-A00L-01 LARGE INTESTINE c.3518G>A p.R1173Q COSMIC PASSENGER/OTHER Benign 91 TCGA-AA-A01Q-01 LARGE INTESTINE c.4580T>C p.L1527P COSMIC PASSENGER/OTHER Benign 92 TCGA-AA-A022-01 LARGE INTESTINE c.2276G>A p.G759D COSMIC PASSENGER/OTHER Probably Damaging 93 TCGA-AG-A002-01 LARGE INTESTINE c.1288C>A p.P430T COSMIC PASSENGER/OTHER Benign 94 TCGA-AG-A002-01 LARGE INTESTINE c.4235C>A p.S1412Y COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-AG-A00C-01 LARGE INTESTINE c.4693G>T p.G1565* COSMIC NP NP 96 TCGA-AG-A020-01 LARGE INTESTINE c.2052A>C p.K684N COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1155 S Phosphorylation 2 1641 Y Phosphorylation 3 871 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR TET1 TET1 TET1 ENSP00000362748 Q8NFU7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8NFU7 TET1 ENSP00000362748 TET1 Q8NFU7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB TET1 ENSP00000362748 607790 Q8NFU7 PA162405605
