dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: UCHL5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 100879 LUNG c.555G>T p.P185P COSMIC NP NP 2 113364 LUNG c.482A>G p.D161G COSMIC PASSENGER/OTHER Benign 3 587376 LARGE INTESTINE c.534A>C p.L178F COSMIC PASSENGER/OTHER Probably Damaging 4 ESO-187 OESOPHAGUS c.67A>C p.K23Q COSMIC PASSENGER/OTHER Benign 5 ESO-2143 OESOPHAGUS c.60G>C p.E20D COSMIC PASSENGER/OTHER Benign 6 HCC2998 LARGE INTESTINE c.632A>G p.Y211C COSMIC PASSENGER/OTHER Probably Damaging 7 LUAD-S01302 LUNG c.492C>G p.H164Q COSMIC CANCER Probably Damaging 8 LUAD-S01405 LUNG c.979G>T p.E327* COSMIC NP NP 9 PCSI_0102_Pa_P NS c.63C>T p.L21L COSMIC NP NP 10 TARGET-30-PARDCK AUTONOMIC GANGLIA c.643G>T p.E215* COSMIC NP NP 11 TCGA-13-0904-01 OVARY c.223G>C p.D75H COSMIC PASSENGER/OTHER Benign 12 TCGA-34-5231-01 LUNG c.8G>T p.G3V COSMIC PASSENGER/OTHER Possibly Damaging 13 TCGA-49-6744-01 LUNG c.751G>A p.D251N COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-73-4668-01 LUNG c.369A>T p.A123A COSMIC NP NP 15 TCGA-75-7027-01 LUNG c.973G>T p.A325S COSMIC PASSENGER/OTHER Benign 16 TCGA-A2-A0T0-01 BREAST c.419A>G p.H140R COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-AA-3510-01 LARGE INTESTINE c.218G>A p.R73Q COSMIC PASSENGER/OTHER Possibly Damaging 18 TCGA-AG-A015-01 LARGE INTESTINE c.964G>A p.A322T COSMIC PASSENGER/OTHER Benign 19 TCGA-AP-A054-01 ENDOMETRIUM c.780T>C p.I260I COSMIC NP NP 20 TCGA-AX-A05Z-01 ENDOMETRIUM c.839G>T p.R280I COSMIC PASSENGER/OTHER Benign 21 TCGA-AX-A06B-01 ENDOMETRIUM c.812T>C p.I271T COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AX-A0J0-01 ENDOMETRIUM c.654T>C p.F218F COSMIC NP NP 23 TCGA-AZ-6606-01 LARGE INTESTINE c.224A>G p.D75G COSMIC PASSENGER/OTHER Benign 24 TCGA-B5-A11E-01 ENDOMETRIUM c.228G>A p.T76T COSMIC NP NP 25 TCGA-BS-A0UV-01 ENDOMETRIUM c.346G>T p.E116* COSMIC NP NP 26 TCGA-BS-A0UV-01 ENDOMETRIUM c.83G>A p.R28Q COSMIC PASSENGER/OTHER Benign 27 TCGA-CA-6717-01 LARGE INTESTINE c.429C>T p.F143F COSMIC NP NP 28 TCGA-CK-5912-01 LARGE INTESTINE c.224A>G p.D75G COSMIC PASSENGER/OTHER Benign 29 TCGA-CM-4746-01 LARGE INTESTINE c.217C>T p.R73* COSMIC NP NP 30 TCGA-D1-A174-01 ENDOMETRIUM c.81C>T p.C27C COSMIC NP NP 31 TCGA-D1-A17S-01 ENDOMETRIUM c.721C>A p.Q241K COSMIC PASSENGER/OTHER Benign 32 TCGA-DI-A0WH-01 ENDOMETRIUM c.432C>T p.A144A COSMIC NP NP 33 TCGA-DR-A0ZM-01 CERVIX c.751G>C p.D251H COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-FD-A3B6-01 URINARY TRACT c.97G>T p.E33* COSMIC NP NP 35 TCGA-FI-A2F8-01 ENDOMETRIUM c.364G>C p.D122H COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-GV-A3JZ-01 URINARY TRACT c.30C>T p.L10L COSMIC NP NP 37 YUAKER SKIN c.467C>T p.S156L COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 126 K Ubiquitylation 2 154 K Ubiquitylation 3 158 K Ubiquitylation 4 158 K Acetylation 5 158 K Acetylation 6 210 K Ubiquitylation 7 234 K Ubiquitylation 8 277 K Ubiquitylation 9 315 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR UCHL5 UCHL5 UCHL5 ENSP00000356418 Q9Y5K5 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y5K5 UCHL5 ENSP00000356418 UCHL5 Q9Y5K5 Expression Atlas Protein Atlas OMIM IntAct PharmGKB UCHL5 ENSP00000356418 610667 Q9Y5K5 PA134916228
