dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: WHSC1L1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2313287 STOMACH c.1581_splice p.K527_splice CCLE NP NP 2 A204 SOFT TISSUE c.119T>C p.I40T CCLE PASSENGER/OTHER Benign 3 BICR18 UPPER AERODIGESTIVE TRACT c.3558G>C p.L1186F CCLE PASSENGER/OTHER Probably Damaging 4 CAL12T LUNG c.2660A>G p.Y887C CCLE PASSENGER/OTHER Possibly Damaging 5 CL14 LARGE INTESTINE c.3925_3926insAAGA p.R1309fs CCLE NP NP 6 COLO775 HAEMATOPOIETIC AND LYMPHOID TISSUE c.597A>C p.K199N CCLE PASSENGER/OTHER Probably Damaging 7 DANG PANCREAS c.1409G>C p.W470S CCLE PASSENGER/OTHER Probably Damaging 8 DV90 LUNG c.1809G>T p.Q603H CCLE PASSENGER/OTHER Probably Damaging 9 EN ENDOMETRIUM c.3197_3198insA p.N1066fs CCLE NP NP 10 EN ENDOMETRIUM c.3734T>C p.L1245P CCLE PASSENGER/OTHER Probably Damaging 11 FU97 STOMACH c.1808A>C p.Q603P CCLE PASSENGER/OTHER Probably Damaging 12 GSS STOMACH c.3455C>T p.T1152M CCLE PASSENGER/OTHER Probably Damaging 13 HCC1569 BREAST c.2758G>T p.G920C CCLE PASSENGER/OTHER Probably Damaging 14 HEC1B ENDOMETRIUM c.587A>G p.K196R CCLE PASSENGER/OTHER Benign 15 HEC251 ENDOMETRIUM c.2869A>C p.K957Q CCLE PASSENGER/OTHER Probably Damaging 16 HEC251 ENDOMETRIUM c.4268A>C p.K1423T CCLE PASSENGER/OTHER Benign 17 HEC265 ENDOMETRIUM c.1708G>T p.G570C CCLE PASSENGER/OTHER Probably Damaging 18 HEC265 ENDOMETRIUM c.381_382insA p.K127fs CCLE NP NP 19 HEC6 ENDOMETRIUM c.3859C>T p.R1287W CCLE PASSENGER/OTHER Probably Damaging 20 HS888T BONE c.3278C>T p.S1093L CCLE PASSENGER/OTHER Probably Damaging 21 HT115 LARGE INTESTINE c.1531A>G p.N511D CCLE PASSENGER/OTHER Possibly Damaging 22 IPC298 SKIN c.2115_splice p.Q705_splice CCLE NP NP 23 IPC298 SKIN c.3830C>G p.A1277G CCLE PASSENGER/OTHER Benign 24 JHUEM1 ENDOMETRIUM c.1255_1255delA p.T419fs CCLE NP NP 25 KYSE410 OESOPHAGUS c.1876T>C p.S626P CCLE PASSENGER/OTHER Probably Damaging 26 MDAPCA2B PROSTATE c.3521A>G p.Y1174C CCLE PASSENGER/OTHER Probably Damaging 27 MEG01 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1225A>G p.S409G CCLE PASSENGER/OTHER Benign 28 MUTZ5 HAEMATOPOIETIC AND LYMPHOID TISSUE c.779C>A p.T260K CCLE PASSENGER/OTHER Benign 29 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1904G>A p.R635H CCLE PASSENGER/OTHER Probably Damaging 30 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2693G>A p.R898H CCLE PASSENGER/OTHER Probably Damaging 31 NCIH1437 LUNG c.1081C>T p.P361S CCLE PASSENGER/OTHER Possibly Damaging 32 NCIH1568 LUNG c.892A>G p.T298A CCLE PASSENGER/OTHER Benign 33 NCIH1944 LUNG c.4151C>G p.S1384* CCLE NP NP 34 NCIH196 LUNG c.3547G>A p.E1183K CCLE PASSENGER/OTHER Probably Damaging 35 NCIH2228 LUNG c.1328_1329insT p.S443fs CCLE NP NP 36 NCIH526 LUNG c.1055A>G p.E352G CCLE PASSENGER/OTHER Probably Damaging 37 NCIH810 LUNG c.1259G>T p.R420L CCLE PASSENGER/OTHER Probably Damaging 38 NUGC3 STOMACH c.2335G>A p.V779I CCLE PASSENGER/OTHER Possibly Damaging 39 OV56 OVARY c.3212C>T p.P1071L CCLE PASSENGER/OTHER Probably Damaging 40 P12ICHIKAWA HAEMATOPOIETIC AND LYMPHOID TISSUE c.1768T>G p.S590A CCLE PASSENGER/OTHER Possibly Damaging 41 SNU175 LARGE INTESTINE c.2447T>C p.M816T CCLE PASSENGER/OTHER Possibly Damaging 42 SNU81 LARGE INTESTINE c.1271C>A p.S424Y CCLE PASSENGER/OTHER Benign 43 SNUC2A LARGE INTESTINE c.3197_3197delA p.N1066fs CCLE NP NP 44 SW1710 URINARY TRACT c.1015T>A p.L339I CCLE PASSENGER/OTHER Probably Damaging 45 SW48 LARGE INTESTINE c.3905_3905delA p.N1302fs CCLE NP NP 46 VMRCLCD LUNG c.2729C>A p.S910* CCLE NP NP 47 WM1799 SKIN c.2339G>A p.R780H CCLE PASSENGER/OTHER Probably Damaging 48 107106 BREAST c.1444T>C p.S482P COSMIC PASSENGER/OTHER Probably Damaging 49 587222 LARGE INTESTINE c.736G>T p.E246* COSMIC NP NP 50 587284 LARGE INTESTINE c.631C>T p.R211C COSMIC PASSENGER/OTHER Probably Damaging 51 587376 LARGE INTESTINE c.1690G>T p.A564S COSMIC PASSENGER/OTHER Benign 52 CLL109 HAEMATOPOIETIC AND LYMPHOID TISSUE c.550G>A p.E184K COSMIC PASSENGER/OTHER Benign 53 ESO-151 OESOPHAGUS c.1261C>T p.R421* COSMIC NP NP 54 HCC69T LIVER c.977G>C p.R326P COSMIC PASSENGER/OTHER Probably Damaging 55 HN_62426 UPPER AERODIGESTIVE TRACT c.1910C>T p.S637F COSMIC PASSENGER/OTHER Probably Damaging 56 LUAD-LIP77 LUNG c.721G>T p.E241* COSMIC NP NP 57 PD4134a BREAST c.1192C>A p.Q398K COSMIC PASSENGER/OTHER Benign 58 PD4252a NS c.196C>G p.L66V COSMIC PASSENGER/OTHER Possibly Damaging 59 RK107_C01 LIVER c.1594A>T p.K532* COSMIC NP NP 60 TCGA-21-5784-01 LUNG c.1126G>A p.E376K COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-24-2288-01 OVARY c.824G>C p.W275S COSMIC CANCER Probably Damaging 62 TCGA-33-4538-01 LUNG c.1552T>C p.F518L COSMIC PASSENGER/OTHER Benign 63 TCGA-39-5016-01 LUNG c.960G>T p.A320A COSMIC NP NP 64 TCGA-39-5030-01 LUNG c.1336G>C p.E446Q COSMIC PASSENGER/OTHER Possibly Damaging 65 TCGA-55-1594-01 LUNG c.632G>A p.R211H COSMIC PASSENGER/OTHER Benign 66 TCGA-66-2768-01 LUNG c.121G>A p.A41T COSMIC PASSENGER/OTHER Benign 67 TCGA-66-2785-01 LUNG c.1309G>C p.E437Q COSMIC PASSENGER/OTHER Benign 68 TCGA-66-2789-01 LUNG c.86G>A p.R29H COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-73-4668-01 LUNG c.1306G>T p.G436W COSMIC PASSENGER/OTHER Probably Damaging 70 TCGA-91-6831-01 LUNG c.933G>A p.Q311Q COSMIC NP NP 71 TCGA-A3-3357-01 KIDNEY c.928G>T p.V310F COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-A5-A0GI-01 ENDOMETRIUM c.261G>A p.Q87Q COSMIC NP NP 73 TCGA-AA-3555-01 LARGE INTESTINE c.1553T>G p.F518C COSMIC PASSENGER/OTHER Possibly Damaging 74 TCGA-AA-A022-01 LARGE INTESTINE c.1667C>T p.T556M COSMIC PASSENGER/OTHER Possibly Damaging 75 TCGA-AP-A051-01 ENDOMETRIUM c.838A>C p.T280P COSMIC PASSENGER/OTHER Benign 76 TCGA-AP-A056-01 ENDOMETRIUM c.1295A>C p.Q432P COSMIC PASSENGER/OTHER Benign 77 TCGA-AP-A056-01 ENDOMETRIUM c.1722G>T p.K574N COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-AP-A056-01 ENDOMETRIUM c.747A>G p.P249P COSMIC NP NP 79 TCGA-AX-A063-01 ENDOMETRIUM c.1168T>C p.Y390H COSMIC PASSENGER/OTHER Probably Damaging 80 TCGA-AX-A0J0-01 ENDOMETRIUM c.1221A>C p.K407N COSMIC PASSENGER/OTHER Probably Damaging 81 TCGA-AX-A0J0-01 ENDOMETRIUM c.806A>G p.Q269R COSMIC PASSENGER/OTHER Benign 82 TCGA-AZ-4315-01 LARGE INTESTINE c.115G>A p.D39N COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-B0-5094-01 KIDNEY c.1418C>T p.A473V COSMIC PASSENGER/OTHER Probably Damaging 84 TCGA-B5-A0JZ-01 ENDOMETRIUM c.1194G>A p.Q398Q COSMIC NP NP 85 TCGA-B5-A0K6-01 ENDOMETRIUM c.701T>C p.V234A COSMIC PASSENGER/OTHER Benign 86 TCGA-B5-A11Z-01 ENDOMETRIUM c.1010A>C p.E337A COSMIC PASSENGER/OTHER Possibly Damaging 87 TCGA-CA-6717-01 LARGE INTESTINE c.1136T>C p.L379S COSMIC PASSENGER/OTHER Probably Damaging 88 cSCCP8 SKIN c.1541G>A p.G514E COSMIC PASSENGER/OTHER Benign 89 ccRCC-12 KIDNEY c.594A>T p.K198N COSMIC PASSENGER/OTHER Possibly Damaging 90 pfg008T STOMACH c.1255delA p.T419fs*8 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1065 K Ubiquitylation 2 1391 K Acetylation 3 1406 S Phosphorylation 4 1415 S Phosphorylation 5 150 S Phosphorylation 6 424 S Phosphorylation 7 556 T Phosphorylation 8 556 T Phosphorylation 9 561 S Phosphorylation 10 571 S Phosphorylation 11 571 S Phosphorylation 12 587 S Phosphorylation 13 590 S Phosphorylation 14 637 S Phosphorylation 15 638 T Phosphorylation 16 671 S Phosphorylation 17 790 K Acetylation 18 790 K Acetylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR WHSC1L1 WHSC1L1 WHSC1L1 ENSP00000313410 Q9BZ95 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9BZ95 WHSC1L1 ENSP00000313410 WHSC1L1 Q9BZ95 Expression Atlas Protein Atlas OMIM IntAct PharmGKB WHSC1L1 ENSP00000313410 607083 Q9BZ95
