dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: YY1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.1124G>A p.R375Q COSMIC PASSENGER/OTHER Probably Damaging 2 CHC1061T LIVER c.1225A>G p.K409E COSMIC PASSENGER/OTHER Probably Damaging 3 HCC97T LIVER c.206_207insCCA p.H80_P81insH COSMIC NP NP 4 LUAD-CHTN-MAD04-00674 LUNG c.528C>T p.G176G COSMIC NP NP 5 P09-1580 PROSTATE c.127_129delGAG p.E43delE COSMIC NP NP 6 PD6746a NS c.1069T>C p.F357L COSMIC PASSENGER/OTHER Probably Damaging 7 TCGA-50-5941-01 LUNG c.1154G>T p.C385F COSMIC CANCER Probably Damaging 8 TCGA-AB-2916-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.759A>G p.E253E COSMIC NP NP 9 TCGA-AG-A002-01 LARGE INTESTINE c.941G>T p.R314I COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-BG-A0M4-01 ENDOMETRIUM c.802A>G p.I268V COSMIC PASSENGER/OTHER Benign 11 TCGA-BG-A0MO-01 ENDOMETRIUM c.207_209delCCA p.H80delH COSMIC NP NP 12 TCGA-BG-A0MU-01 ENDOMETRIUM c.283_284delAC p.T95fs*52 COSMIC NP NP 13 TCGA-D1-A16N-01 ENDOMETRIUM c.207_209delCCA p.H80delH COSMIC NP NP 14 TCGA-DS-A0VN-01 CERVIX c.381C>T p.F127F COSMIC NP NP 15 TCGA-EJ-5499-01 PROSTATE c.759A>G p.E253E COSMIC NP NP 16 TCGA-EJ-5503-01 PROSTATE c.759A>G p.E253E COSMIC NP NP 17 WA26 PROSTATE c.367G>A p.A123T COSMIC PASSENGER/OTHER Benign 18 cSCCP7 SKIN c.1082G>A p.G361E COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
