ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CYP19A1	1588	17507620	-	Polymorphism	-	-	-	-	30 to 69	-	Sanghai; China	-	-	[1] CYP19A1 genetic polymorphisms; including rs1065779; rs700519; rs28566535; rs752760; rs1870050; in relation to endometrial cancer risk in a case-control study. [2] An inverse association between CYP19A1 haplotype TCATC and endometrial cancer in our population (OR; 0.76; 95% CI; 0.62-0.92). An inverse association was found between endometrial cancer and single nucleotide polymorphism rs1870050 in the promoter region with ORs of 0.81 (95% CI; 0.68-0.97) and 0.58 (95% CI; 0.42-0.80) for the AC and CC genotypes; respectively. [3] A multiplicative interaction between single nucleotide polymorphism rs700519 and body mass index among postmenopausal women (P = 0.01); with stronger associations between rs700519 genotypes and endometrial cancer risk among heavier (body mass index; >or=25) postmenopausal women.	Polymorphisms in the CYP19A1 (aromatase) gene and endometrial cancer risk in Chinese women.	Cancer epidemiology; biomarkers & prevention	16(5):943-9	2007