ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
MDM2	4193	17123590	-	Polymorphism	-	-	79	73 (62 Endometriod; 11 UPSC/Mixed )	-	-	-	I (n=46); II (n=8); III (n=11); IV (n=8)	1 (n=34); 2 (n=21); 3 (n=10)	[1] The MDM2 SNP309 homozygous G/G genotype may be a genetic variant that influences sporadic endometrial cancer susceptibility. [2] The homozygous G/G genotype was found in 25% of endometrial cancer cases and 11% of controls. In an age-adjusted analysis of cases and controls; the G/G genotype increased the risk of endometrial cancer 2.76-fold (95% CI: 1.06; 7.20; p=0.03) compared to presence of a wild-type T allele (T/G and T/T genotypes).	Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk	Gynecologic Oncology	104(3):660-4	2007
MDM2	4193	18398041	-	Polymorphism	-	-	1543	591	30 to 55	-	Brigham and Women's Hospital and Harvard Medical School; Boston; Masssachutts	-	-	[1] Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer. [2] Women with a homozygous variant genotype had a greater risk than women with a wild-type genotype for the MDM2 SNP309 (covariate-adjusted odds ratio; 1.87; 95% confidence interval; 1.29-2.73) for endometrial cancer.	MDM2 SNP309 is associated with endometrial cancer risk.	Cancer epidemiology; biomarkers & prevention	17(4):983-6	2008