| Experimental Information |
| |
| Enzymatic Activity |
| Molecule Id | EGIN0004881 |
| PMID | 17349580 |
| Assay Used | fluorescence quenching assay |
| Experimently Validated | Yes |
| EGFR (IC50) | - |
| HER2 (IC50) | - |
| HER4 (IC50) | - |
| Mutant L858R (IC50) | - |
| Mutant T790M (IC50) | - |
| Double Mutant (IC50) | - |
| Average ERBB2 and ERBB1 (IC50) | - |
| Inhibition EGFR (%) | - |
| Inhibitory Concentration | - |
| Inhibition HER2 (%) | - |
| Inhibitory Concentration | - |
| Ki (EGFR) | - |
| Ki (HER2) | - |
| Ki (HER4) | - |
| Kd (EGFR) | 10.9±3.3 nM |
| Kd (L858R) | 1.7±0.4 nM |
| Kd (T790M) | - |
| Kd (L858R/T790M) | - |
| Kd (Other mutation) | 11.3±1.5 nM |
| Note | The paper describes the Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity. |
| Extra | - |
| |
