| Experimental Information |
| |
| Enzymatic Activity |
| Molecule Id | EGIN0000370 |
| PMID | 15993078 |
| Assay Used | Phosphorylation of a peptide substrate in the presence of 10 µM inhibitor and Cellular assay |
| Experimently Validated | Yes |
| EGFR (IC50) | - |
| HER2 (IC50) | - |
| HER4 (IC50) | - |
| Mutant L858R (IC50) | - |
| Mutant T790M (IC50) | - |
| Double Mutant (IC50) | - |
| Average ERBB2 and ERBB1 (IC50) | - |
| Inhibition EGFR (%) | 21.10% |
| Inhibitory Concentration | 10 µM |
| Inhibition HER2 (%) | 7.20% |
| Inhibitory Concentration | % inhibition at 10 µM |
| Ki (EGFR) | - |
| Ki (HER2) | - |
| Ki (HER4) | - |
| Kd (EGFR) | - |
| Kd (L858R) | - |
| Kd (T790M) | - |
| Kd (L858R/T790M) | - |
| Kd (Other mutation) | - |
| Note | The paper describes the 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling inhibitors |
| Extra | - |
| |
