| Experimental Information |
| |
| Enzymatic Activity |
| Molecule Id | EGIN0001038 |
| PMID | 11495584 |
| Assay Used | Autophosphorylation of EGFR and HER-2 Kinases using a solid-phase ELISA assay and Cell Growth Inhibitory Activity |
| Experimently Validated | Yes |
| EGFR (IC50) | 12 nM |
| HER2 (IC50) | 38 nM |
| HER4 (IC50) | - |
| Mutant L858R (IC50) | - |
| Mutant T790M (IC50) | - |
| Double Mutant (IC50) | - |
| Average ERBB2 and ERBB1 (IC50) | - |
| Inhibition EGFR (%) | - |
| Inhibitory Concentration | - |
| Inhibition HER2 (%) | - |
| Inhibitory Concentration | - |
| Ki (EGFR) | - |
| Ki (HER2) | - |
| Ki (HER4) | - |
| Kd (EGFR) | - |
| Kd (L858R) | - |
| Kd (T790M) | - |
| Kd (L858R/T790M) | - |
| Kd (Other mutation) | - |
| Note | The paper describes the 6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases. |
| Extra | - |
| |
