Experimental Information |
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Enzymatic Activity |
Molecule Id | EGIN0001042 |
PMID | 11495584 |
Assay Used | Autophosphorylation of EGFR and HER-2 Kinases using a solid-phase ELISA assay and Cell Growth Inhibitory Activity |
Experimently Validated | Yes |
EGFR (IC50) | 71 nM |
HER2 (IC50) | 85 nM |
HER4 (IC50) | - |
Mutant L858R (IC50) | - |
Mutant T790M (IC50) | - |
Double Mutant (IC50) | - |
Average ERBB2 and ERBB1 (IC50) | - |
Inhibition EGFR (%) | - |
Inhibitory Concentration | - |
Inhibition HER2 (%) | - |
Inhibitory Concentration | - |
Ki (EGFR) | - |
Ki (HER2) | - |
Ki (HER4) | - |
Kd (EGFR) | - |
Kd (L858R) | - |
Kd (T790M) | - |
Kd (L858R/T790M) | - |
Kd (Other mutation) | - |
Note | The paper describes the 6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases. |
Extra | - |
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