Experimental Information |
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Enzymatic Activity |
Molecule Id | EGIN0001868 |
PMID | 16777410 |
Assay Used | Inhibition of ErbB-1 and ErbB-2 tyrosine Kinase activity was evaluated in Enzyme assays using the purified recombinant human intracellular domain of each receptor and Cellular assay |
Experimently Validated | Yes |
EGFR (IC50) | 100 nM |
HER2 (IC50) | 90 nM |
HER4 (IC50) | - |
Mutant L858R (IC50) | - |
Mutant T790M (IC50) | - |
Double Mutant (IC50) | - |
Average ERBB2 and ERBB1 (IC50) | - |
Inhibition EGFR (%) | - |
Inhibitory Concentration | - |
Inhibition HER2 (%) | - |
Inhibitory Concentration | - |
Ki (EGFR) | - |
Ki (HER2) | - |
Ki (HER4) | - |
Kd (EGFR) | - |
Kd (L858R) | - |
Kd (T790M) | - |
Kd (L858R/T790M) | - |
Kd (Other mutation) | - |
Note | The paper describes 6-furanylquinazoline series of dual ErbB-1/ErbB-2 tyrosine kinase inhibitors |
Extra | - |
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