| Experimental Information |
| |
| Enzymatic Activity |
| Molecule Id | EGIN0002889 |
| PMID | 8145236 |
| Assay Used | Tyrosine Kinase activity associated with EGFR was evaluated using ER 22 cell membranes as an enzyme source and the tridecapeptide RR-Src (RRLIEDAEYAARG) as the phosphoryl-acceptor substrate |
| Experimently Validated | Yes |
| EGFR (IC50) | 3000 nM |
| HER2 (IC50) | - |
| HER4 (IC50) | - |
| Mutant L858R (IC50) | - |
| Mutant T790M (IC50) | - |
| Double Mutant (IC50) | - |
| Average ERBB2 and ERBB1 (IC50) | - |
| Inhibition EGFR (%) | - |
| Inhibitory Concentration | - |
| Inhibition HER2 (%) | - |
| Inhibitory Concentration | - |
| Ki (EGFR) | - |
| Ki (HER2) | - |
| Ki (HER4) | - |
| Kd (EGFR) | - |
| Kd (L858R) | - |
| Kd (T790M) | - |
| Kd (L858R/T790M) | - |
| Kd (Other mutation) | - |
| Note | the paper describes the 5-[(2,5-Dihydroxybenzyl)amino]salicylate Inhibitors of EGF-Receptor |
| Extra | - |
| |
