| Experimental Information |
| |
| Enzymatic Activity |
| Molecule Id | EGIN0004148 |
| PMID | 18610999 |
| Assay Used | Enzymatic assay |
| Experimently Validated | Yes |
| EGFR (IC50) | 3400 ± 630 nM |
| HER2 (IC50) | 960± 250 nM |
| HER4 (IC50) | - |
| Mutant L858R (IC50) | - |
| Mutant T790M (IC50) | - |
| Double Mutant (IC50) | - |
| Average ERBB2 and ERBB1 (IC50) | - |
| Inhibition EGFR (%) | 92.4%,73.2% |
| Inhibitory Concentration | 10µM,10µM(cell free system) |
| Inhibition HER2 (%) | 97.60% |
| Inhibitory Concentration | % inhibition at 10µM(cell free system) |
| Ki (EGFR) | - |
| Ki (HER2) | - |
| Ki (HER4) | - |
| Kd (EGFR) | - |
| Kd (L858R) | - |
| Kd (T790M) | - |
| Kd (L858R/T790M) | - |
| Kd (Other mutation) | - |
| Note | The paper describes the naturally occurring homoisoflavonoids function as potent Protein Tyrosine Kinase Inhibitors by c-Src-Based High-Throughput Screening |
| Extra | - |
| |
