Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0000002 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | VEGFR2 | - | 820 nM | - | - | - | - | - | - | - |
| 2 | cSrc | SM (C345) | 990 nM | - | - | - | - | - | - | - |
| 3 | cSrc | DM(C345/M338) | 15000 nM | - | - | - | - | - | - | - |
| 4 | A431 | - | 420 nM | - | - | - | - | - | - | - |
| 5 | SK-BR-3 | - | 1890 nM | - | - | - | - | - | - | - |
| 6 | pIGF-1R | - | >10000 nM | - | - | - | - | - | - | - |
| 7 | VEGFR-2 | - | 124700± 18200 nM | - | - | - | - | - | - | - |
| 8 | PDGFR-ß | - | 83100 ± 10100 nM | - | - | - | - | - | - | - |
| 9 | pIGF1R | - | >30000 nM | - | - | - | - | - | - | - |
| 10 | pEGFR | - | 51 nM | - | - | - | - | - | - | - |
| 11 | pErbB2 | - | 6730 nM | - | - | - | - | - | - | - |
| 12 | VEGFR2 | - | 820 nM | - | - | - | - | - | - | - |
