Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0001998 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Axl | - | >10000nM | - | - | - | - | - | - | - |
| 2 | CDK2 | - | >10000nM | - | - | - | - | - | - | - |
| 3 | c-Met | - | >10000nM | - | - | - | - | - | - | - |
| 4 | FLT3 | - | >10000nM | - | - | - | - | - | - | - |
| 5 | IGF1R | - | >10000nM | - | - | - | - | - | - | - |
| 6 | JAK2 | - | >10000nM | - | - | - | - | - | - | - |
| 7 | PKA | - | >10000nM | - | - | - | - | - | - | - |
| 8 | PKB | - | >10000nM | - | - | - | - | - | - | - |
| 9 | PDGFR beta | - | 1400nM | - | - | - | - | - | - | - |
| 10 | BRAF | V599E | 150nM | - | - | - | - | - | - | - |
| 11 | c-Abl | - | 250nM | - | - | - | - | - | - | - |
| 12 | TIE2 | - | 300nM | - | - | - | - | - | - | - |
| 13 | P38 | - | 350nM | - | - | - | - | - | - | - |
| 14 | EphB4 | - | 430nM | - | - | - | - | - | - | - |
| 15 | FGFR1 | - | 570nM | - | - | - | - | - | - | - |
| 16 | c-Src | - | 66nM | - | - | - | - | - | - | - |
| 17 | c-Kit | - | 930nM | - | - | - | - | - | - | - |
| 18 | KDR | - | 960nM | - | - | - | - | - | - | - |
