Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003428 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | AKT | - | >5000 nM | - | - | - | - | - | - | - |
| 2 | CaMKII | - | >50000 nM | - | - | - | - | - | - | - |
| 3 | CDK2 | - | >10000 nM | - | - | - | - | - | - | - |
| 4 | c-kit | - | 370nM | - | - | - | - | - | - | - |
| 5 | FGFR1 | - | >5000 nM | - | - | - | - | - | - | - |
| 6 | Flk-1 | - | 40nM | - | - | - | - | - | - | - |
| 7 | GSK-3 | - | >5000 nM | - | - | - | - | - | - | - |
| 8 | IGF1R | - | >25000 nM | - | - | - | - | - | - | - |
| 9 | IKK | - | >10000 nM | - | - | - | - | - | - | - |
| 10 | Itk | - | >50000 nM | - | - | - | - | - | - | - |
| 11 | JAK3 | - | >50000 nM | - | - | - | - | - | - | - |
| 12 | Lck | - | >50000 nM | - | - | - | - | - | - | - |
| 13 | MAPKAPK2 | - | >50000 nM | - | - | - | - | - | - | - |
| 14 | MEK | - | >5000 nM | - | - | - | - | - | - | - |
| 15 | p38 | - | >5000 nM | - | - | - | - | - | - | - |
| 16 | PDGFR beta | - | 200nM | - | - | - | - | - | - | - |
| 17 | PKC alpha | - | >40000 nM | - | - | - | - | - | - | - |
| 18 | PKC beta | - | >40000 nM | - | - | - | - | - | - | - |
| 19 | PKC tau | - | >40000 nM | - | - | - | - | - | - | - |
| 20 | PKC zeta | - | >40000 nM | - | - | - | - | - | - | - |
| 21 | Src | - | >10000 nM | - | - | - | - | - | - | - |
| 22 | SRPK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 23 | Syk | - | >50000 nM | - | - | - | - | - | - | - |
| 24 | VEGFR1 | - | 400nM | - | - | - | - | - | - | - |
| 25 | VEGFR2 | - | 23nM | - | - | - | - | - | - | - |
