Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004047 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | p38 beta | - | <100nM | - | - | - | - | - | - | - |
| 2 | IKK | - | >10000nM | - | - | - | - | - | - | - |
| 3 | cdk2 | - | >100000nM | - | - | - | - | - | - | - |
| 4 | MEK | - | >25000nM | - | - | - | - | - | - | - |
| 5 | KDR | - | >30000nM | - | - | - | - | - | - | - |
| 6 | p38 delta | - | >30000nM | - | - | - | - | - | - | - |
| 7 | p38 gamma | - | >30000nM | - | - | - | - | - | - | - |
| 8 | Raf | - | >30000nM | - | - | - | - | - | - | - |
| 9 | ERK | - | >5000nM | - | - | - | - | - | - | - |
| 10 | Akt | - | >50000nM | - | - | - | - | - | - | - |
| 11 | CaMKII | - | >50000nM | - | - | - | - | - | - | - |
| 12 | FGF | - | >50000nM | - | - | - | - | - | - | - |
| 13 | GSK-3 | - | >50000nM | - | - | - | - | - | - | - |
| 14 | IGF1R | - | >50000nM | - | - | - | - | - | - | - |
| 15 | Itk | - | >50000nM | - | - | - | - | - | - | - |
| 16 | JAK3 | - | >50000nM | - | - | - | - | - | - | - |
| 17 | Lck | - | >50000nM | - | - | - | - | - | - | - |
| 18 | Met | - | >50000nM | - | - | - | - | - | - | - |
| 19 | MK2 | - | >50000nM | - | - | - | - | - | - | - |
| 20 | PKA | - | >50000nM | - | - | - | - | - | - | - |
| 21 | PKC | - | >50000nM | - | - | - | - | - | - | - |
| 22 | Syk | - | >50000nM | - | - | - | - | - | - | - |
| 23 | p38 alpha | - | 4.1nM | - | - | - | - | - | - | - |
