Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004153 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Aurora2 | - | 116nM | - | - | - | - | - | - | - |
| 2 | BTK | - | 19nM | - | - | - | - | - | - | - |
| 3 | CDK5 | - | >100000 nM | - | - | - | - | - | - | - |
| 4 | cFMS | - | 37nM | - | - | - | - | - | - | - |
| 5 | ERK1 | - | >100000 nM | - | - | - | - | - | - | - |
| 6 | FgfRK | - | >1000 nM | - | - | - | - | - | - | - |
| 7 | FgfRK2 | - | >1000 nM | - | - | - | - | - | - | - |
| 8 | Flt1 | - | >1000 nM | - | - | - | - | - | - | - |
| 9 | Flt4 | - | 120nM | - | - | - | - | - | - | - |
| 10 | JAK2 | - | >25000 nM | - | - | - | - | - | - | - |
| 11 | JAK3 | - | >8300 nM | - | - | - | - | - | - | - |
| 12 | JNK2 | - | >100000 nM | - | - | - | - | - | - | - |
| 13 | LCK | - | 8nM | - | - | - | - | - | - | - |
| 14 | MSK1 | - | >100000 nM | - | - | - | - | - | - | - |
| 15 | P38 | - | >25000 nM | - | - | - | - | - | - | - |
| 16 | P70S6 | - | 10000nM | - | - | - | - | - | - | - |
| 17 | PIM1 | - | >30000 nM | - | - | - | - | - | - | - |
| 18 | PIM2 | - | >25000 nM | - | - | - | - | - | - | - |
| 19 | PKA alpha | - | >100000 nM | - | - | - | - | - | - | - |
| 20 | PKB alpha | - | >100000 nM | - | - | - | - | - | - | - |
| 21 | Tie2 | - | 285nM | - | - | - | - | - | - | - |
| 22 | ZAP70 | - | >5400 nM | - | - | - | - | - | - | - |
