Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004158 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | B-RAF | V600E | 1200nM | - | - | - | - | - | - | - |
| 2 | EPHB4 | - | 2300nM | - | - | - | - | - | - | - |
| 3 | InsR | - | 2600nM | - | - | - | - | - | - | - |
| 4 | CDK4/CycD1 | - | 2700nM | - | - | - | - | - | - | - |
| 5 | MET | - | 3300nM | - | - | - | - | - | - | - |
| 6 | CDK2/CycA | - | 3600nM | - | - | - | - | - | - | - |
| 7 | SRC | - | 3800nM | - | - | - | - | - | - | - |
| 8 | IGF1R | - | 4000nM | - | - | - | - | - | - | - |
| 9 | VEGFR2 | - | 4100nM | - | - | - | - | - | - | - |
| 10 | PDGFR beta | - | 4200nM | - | - | - | - | - | - | - |
| 11 | AXL | - | 4400nM | - | - | - | - | - | - | - |
| 12 | FAK | - | 4400nM | - | - | - | - | - | - | - |
| 13 | VEGFR3 | - | 4700nM | - | - | - | - | - | - | - |
| 14 | AKT | - | 9000nM | - | - | - | - | - | - | - |
| 15 | PLK1 | - | 9900nM | - | - | - | - | - | - | - |
