Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004169 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | AurB | - | 78nM | - | - | - | - | - | - | - |
| 2 | Axl | - | 1.1nM | - | - | - | - | - | - | - |
| 3 | BTK | - | >2000 nM | - | - | - | - | - | - | - |
| 4 | CDK2E | - | >2000 nM | - | - | - | - | - | - | - |
| 5 | EGFR | - | >2000 nM | - | - | - | - | - | - | - |
| 6 | FLT3 | - | 16nM | - | - | - | - | - | - | - |
| 7 | GSK-3 beta | - | >2000 nM | - | - | - | - | - | - | - |
| 8 | IGFR1R | - | >2000 nM | - | - | - | - | - | - | - |
| 9 | IKK1/2 | - | >2000 nM | - | - | - | - | - | - | - |
| 10 | InsR | - | >2000 nM | - | - | - | - | - | - | - |
| 11 | Jak2 | - | >2000 nM | - | - | - | - | - | - | - |
| 12 | Lck | - | 120nM | - | - | - | - | - | - | - |
| 13 | Mer | - | 14nM | - | - | - | - | - | - | - |
| 14 | Met | - | 3.9nM | - | - | - | - | - | - | - |
| 15 | MK2 | - | >2000 nM | - | - | - | - | - | - | - |
| 16 | P38a | - | >2000 nM | - | - | - | - | - | - | - |
| 17 | PIM1 | - | >2000 nM | - | - | - | - | - | - | - |
| 18 | PKA | - | 550nM | - | - | - | - | - | - | - |
| 19 | PlK1/3 | - | >2000 nM | - | - | - | - | - | - | - |
| 20 | Ron | - | 1.8nM | - | - | - | - | - | - | - |
| 21 | TrkA | - | 290nM | - | - | - | - | - | - | - |
| 22 | TrkB | - | 190nM | - | - | - | - | - | - | - |
| 23 | Tyro3 | - | 4.3nM | - | - | - | - | - | - | - |
| 24 | VEGFR2 | - | 180nM | - | - | - | - | - | - | - |
