Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004173 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | ARK5 | - | 3.8 µg/mL | - | - | - | - | - | - | - |
| 2 | Aurora A | - | 2.8 µg/mL | - | - | - | - | - | - | - |
| 3 | Aurora B | - | 2.4 µg/mL | - | - | - | - | - | - | - |
| 4 | B-RAF-VE | - | 6.5 µg/mL | - | - | - | - | - | - | - |
| 5 | CDK4/CycD1 | - | 4.7 µg/mL | - | - | - | - | - | - | - |
| 6 | COT | - | 4.2 µg/mL | - | - | - | - | - | - | - |
| 7 | EPHB4 | - | 4.2 µg/mL | - | - | - | - | - | - | - |
| 8 | FAK | - | 5.5 µg/mL | - | - | - | - | - | - | - |
| 9 | FLT3 | - | 2.8 µg/mL | - | - | - | - | - | - | - |
| 10 | IGF1R | - | 1.9 µg/mL | - | - | - | - | - | - | - |
| 11 | InsR | - | 3.7 µg/mL | - | - | - | - | - | - | - |
| 12 | MET | - | 6.4 µg/mL | - | - | - | - | - | - | - |
| 13 | PDGFR beta | - | 6.4 µg/mL | - | - | - | - | - | - | - |
| 14 | SAK | - | 1.4 µg/mL | - | - | - | - | - | - | - |
| 15 | SRC | - | 1.7 µg/mL | - | - | - | - | - | - | - |
| 16 | TIE2 | - | 3.3 µg/mL | - | - | - | - | - | - | - |
| 17 | VEGFR2 | - | 3.4 µg/mL | - | - | - | - | - | - | - |
| 18 | VEGFR3 | - | 4 µg/mL | - | - | - | - | - | - | - |
