| Activity against kinases |
| Molecule Id: EGIN0004340 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Lck | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 3 | 10 然 | - | - | - |
| 2 | YES1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 7 | 10 然 | - | - | - |
| 3 | PHK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 10 | 10 然 | - | - | - |
| 4 | RIPK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 10 | 10 然 | - | - | - |
| 5 | PIM1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 12 | 10 然 | - | - | - |
| 6 | MNK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 14 | 10 然 | - | - | - |
| 7 | EPH-B3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 17 | 10 然 | - | - | - |
| 8 | PKD1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 18 | 10 然 | - | - | - |
| 9 | SmMLCK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 18 | 10 然 | - | - | - |
| 10 | AuroraB | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 21 | 10 然 | - | - | - |
| 11 | DYRK3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 27 | 10 然 | - | - | - |
| 12 | BRSK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 29 | 10 然 | - | - | - |
| 13 | MKK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 29 | 10 然 | - | - | - |
| 14 | PIM3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 32 | 10 然 | - | - | - |
| 15 | MINK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 35 | 10 然 | - | - | - |
| 16 | FGF-R1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 37 | 10 然 | - | - | - |
| 17 | PRK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 37 | 10 然 | - | - | - |
| 18 | CHK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 38 | 10 然 | - | - | - |
| 19 | NUAK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 39 | 10 然 | - | - | - |
| 20 | Src | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 44 | 10 然 | - | - | - |
| 21 | GCK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 48 | 10 然 | - | - | - |
| 22 | MELK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 49 | 10 然 | - | - | - |
| 23 | MetNK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 49 | 10 然 | - | - | - |
| 24 | VEGFR | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 50 | 10 然 | - | - | - |
| 25 | DYRK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 51 | 10 然 | - | - | - |
| 26 | BRSK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 52 | 10 然 | - | - | - |
| 27 | EPH-A2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 53 | 10 然 | - | - | - |
| 28 | CAMK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 57 | 10 然 | - | - | - |
| 29 | PIM2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 62 | 10 然 | - | - | - |
| 30 | CSK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 63 | 10 然 | - | - | - |
| 31 | p38a | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 63 | 10 然 | - | - | - |
| 32 | AMPK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 65 | 10 然 | - | - | - |
| 33 | DYRK1A | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 65 | 10 然 | - | - | - |
| 34 | MLK3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 65 | 10 然 | - | - | - |
| 35 | AuroraA | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 66 | 10 然 | - | - | - |
| 36 | CAMKKb | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 66 | 10 然 | - | - | - |
| 37 | CK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 66 | 10 然 | - | - | - |
| 38 | SYK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 67 | 10 然 | - | - | - |
| 39 | ERK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 70 | 10 然 | - | - | - |
| 40 | IRR | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 70 | 10 然 | - | - | - |
| 41 | PKCa | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 72 | 10 然 | - | - | - |
| 42 | RSK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 72 | 10 然 | - | - | - |
| 43 | MARK4 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 74 | 10 然 | - | - | - |
| 44 | PAK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 75 | 10 然 | - | - | - |
| 45 | S6K1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 75 | 10 然 | - | - | - |
| 46 | TBK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 75 | 10 然 | - | - | - |
| 47 | JNK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 76 | 10 然 | - | - | - |
| 48 | JNK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 77 | 10 然 | - | - | - |
| 49 | NEK6 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 77 | 10 然 | - | - | - |
| 50 | ERK8 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 78 | 10 然 | - | - | - |
| 51 | MST2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 78 | 10 然 | - | - | - |
| 52 | RSK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 78 | 10 然 | - | - | - |
| 53 | BTK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 79 | 10 然 | - | - | - |
| 54 | CHK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 79 | 10 然 | - | - | - |
| 55 | IR-HIS | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 79 | 10 然 | - | - | - |
| 56 | p38d | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 79 | 10 然 | - | - | - |
| 57 | PAK6 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 79 | 10 然 | - | - | - |
| 58 | JNK3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 80 | 10 然 | - | - | - |
| 59 | PKBb | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 80 | 10 然 | - | - | - |
| 60 | IRAK4 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 81 | 10 然 | - | - | - |
| 61 | MAPKAP-K3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 81 | 10 然 | - | - | - |
| 62 | p38b | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 81 | 10 然 | - | - | - |
| 63 | MARK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 82 | 10 然 | - | - | - |
| 64 | PAK4 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 83 | 10 然 | - | - | - |
| 65 | PAK5 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 84 | 10 然 | - | - | - |
| 66 | p38g | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 85 | 10 然 | - | - | - |
| 67 | MARK3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 86 | 10 然 | - | - | - |
| 68 | PKCz | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 86 | 10 然 | - | - | - |
| 69 | TTK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 86 | 10 然 | - | - | - |
| 70 | MLK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 87 | 10 然 | - | - | - |
| 71 | SRPK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 87 | 10 然 | - | - | - |
| 72 | ERK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 88 | 10 然 | - | - | - |
| 73 | MST4 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 88 | 10 然 | - | - | - |
| 74 | PDK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 88 | 10 然 | - | - | - |
| 75 | IKKe | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 89 | 10 然 | - | - | - |
| 76 | PRAK | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 89 | 10 然 | - | - | - |
| 77 | IKKB | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 90 | 10 然 | - | - | - |
| 78 | MAPKAP-K2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 90 | 10 然 | - | - | - |
| 79 | EF2K | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 91 | 10 然 | - | - | - |
| 80 | PKA | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 91 | 10 然 | - | - | - |
| 81 | CDK2-CycA | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 93 | 10 然 | - | - | - |
| 82 | MSK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 93 | 10 然 | - | - | - |
| 83 | SGK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 93 | 10 然 | - | - | - |
| 84 | PLK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 95 | 10 然 | - | - | - |
| 85 | ROCK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 95 | 10 然 | - | - | - |
| 86 | CK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 96 | 10 然 | - | - | - |
| 87 | GSK3b | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 96 | 10 然 | - | - | - |
| 88 | HIPK2 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 97 | 10 然 | - | - | - |
| 89 | NEK2a | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 97 | 10 然 | - | - | - |
| 90 | LKB1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 103 | 10 然 | - | - | - |
| 91 | PKBa | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 103 | 10 然 | - | - | - |
| 92 | IGF-1R | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 105 | 10 然 | - | - | - |
| 93 | HIPK3 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 106 | 10 然 | - | - | - |
| 94 | HIPK1 | %ACTIVITY RELATIVE TO 100%DMSO | - | - | - | 126 | 10 然 | - | - | - |