A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10318
Swiss-prot Accession numberQ04618 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin B precursor (Pro-opiomelanocortin B) (POMC B)[Contains: NPP 2; Corticotropin (Adrenocorticotropic hormone) (ACTH);Melanotropin alpha 2 (Alpha-MSH 2); Corticotropin-like intermediarypeptide 2 (CLIP-2); Lipotropin beta (Beta-LPH); Lipotropin gamma(Gamma-LPH); Melanotropin beta 2 (Beta-MSH 2); Beta-endorphin 2; Met-enkephalin].
Source organismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus.
Subcellular locationN/A
Developmental StageExpressed only in sexually active fish.
Similarity Belongs to the POMC family.
Tissue SpecificityPituitary and hypothalamus of adult diploid animals
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides. Acetylation of beta-endorphin occurs in a tissue-specific manner.
FunctionN/A
Protein Length240 Amino acids
Molecular weight26719
References1  PubMed abstract 1448114
2  PubMed abstract 1448114
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameMelanotropin beta 2
Mature Hormone SequenceDGSYRMGHFRWGSPTAI
Position of mature hormone in Pre-Hormone protein17 Residues from position (193-209)
ReceptorQ6QLQ0   Detail in HMRbase   
Q6QLQ1    Detail in HMRbase   
Gene ID100136772      
PDB IDN/A
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