A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10348
Swiss-prot Accession numberQ9BDJ6 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationSecreted protein (By similarity)
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityN/A
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-97 is essential for obestatin activity (By similarity).
Function Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Protein Length116 Amino acids
Molecular weight12793
References1   Kita K., Harada K., Yokota H.; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
2   Li C., Lobo S., Wang Z., Fu A., Meng Y., Murdoch B., Hansen C.,Moore S.; "A full length genomic sequence of the bovine ghrelin gene."; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
3   Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameObestatin
Mature Hormone SequenceFNAPFNIGIKLAGAQSLQHGQTL
Position of mature hormone in Pre-Hormone protein23 Residues from position (75-97)
ReceptorQ9BDH9   Detail in HMRbase   
Q9N1F8   Detail in HMRbase   
Q9TUJ0   Detail in HMRbase   
Q9TUJ1    Detail in HMRbase   
Gene ID281192      
PDB IDN/A
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