A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11266
Swiss-prot Accession numberP01191 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin] (Fragment).
Source organismOvis aries (Sheep)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length212 Amino acids
Molecular weight23464
References1  PubMed abstract 8384993
2   Leonis J., Li C.H., Chung D.; "Corticotropins (ACTH). XV. The action of chymotrypsin on alpha-corticotropin."; J. Am. Chem. Soc. 81:419-423(1959).
3  PubMed abstract 4344689
4  PubMed abstract 4370084
5  PubMed abstract 13929167
6  PubMed abstract 4162144
7  PubMed abstract 4675453
8  PubMed abstract 4270658
9  PubMed abstract 843377
10  PubMed abstract 8384993
11   Leonis J., Li C.H., Chung D.; "Corticotropins (ACTH). XV. The action of chymotrypsin on alpha-corticotropin."; J. Am. Chem. Soc. 81:419-423(1959).
12  PubMed abstract 4344689
13  PubMed abstract 4370084
14  PubMed abstract 13929167
15  PubMed abstract 4162144
16  PubMed abstract 4675453
17  PubMed abstract 4270658
18  PubMed abstract 843377
Domain NameACTH_domain  Op_neuropeptide  
Hormone NameMelanotropin gamma (Gamma-MSH)
Mature Hormone SequenceYVMGHFRWDRF
Position of mature hormone in Pre-Hormone protein11 Residues from position (26-36)
ReceptorQ9TU77   Detail in HMRbase   
O19037    Detail in HMRbase   
Gene IDN/A
PDB IDN/A
Drugpediawiki
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