A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11363
Swiss-prot Accession numberP04090 (Sequence in FASTA format)
DescriptionProrelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the insulin family.
Tissue SpecificityIsoform 1 expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 relatively abundant in placenta, much lower abundance in the prostate gland. Not detected in the ovary
Post translational modificationN/A
Function Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix
Protein Length185 Amino acids
Molecular weight21043
References1  PubMed abstract 6548702
2  PubMed abstract 15164053
3  PubMed abstract 15489334
4  PubMed abstract 8735594
5  PubMed abstract 10601981
6  PubMed abstract 1572287
7  PubMed abstract 2076464
8  PubMed abstract 2040595
9  PubMed abstract 1656049
Domain NameInsulin  
Hormone NameRelaxin A chain
Mature Hormone SequenceQLYSALANKCCHVGCTKRSLARFC
Position of mature hormone in Pre-Hormone protein24 Residues from position (162-185)
ReceptorQ9HBX9   Detail in HMRbase   
Q8WXD0    Detail in HMRbase   
Gene ID6019      
PDB ID6RLX      
Drugpediawiki
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