A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11423
Swiss-prot Accession numberP20382 (Sequence in FASTA format)
DescriptionPro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the melanin-concentrating hormone family.
Tissue SpecificityPredominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly
Post translational modification Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
FunctionN/A
Protein Length165 Amino acids
Molecular weight18723
References1  PubMed abstract 2149166
2  PubMed abstract 8326825
3  PubMed abstract 10037747
4  PubMed abstract 9191099
Domain NamePro-MCH  
Hormone NameNeuropeptide-glutamic acid-isoleucine
Mature Hormone SequenceEIGDEENSAKFPI
Position of mature hormone in Pre-Hormone protein13 Residues from position (131-143)
ReceptorQ99705   Detail in HMRbase   
Q969V1    Detail in HMRbase   
Gene IDN/A
PDB IDN/A
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