A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11531
Swiss-prot Accession numberP41159 (Sequence in FASTA format)
DescriptionLeptin;Alternative Name: Obesity factor;Alternative Name: Obese protein; Precursor
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the leptin family.
Tissue SpecificityN/A
Post translational modification N/A
Function May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Protein Length167 Amino acids
Molecular weight18641
References1  PubMed abstract 7984236
2  PubMed abstract 7789654
3  PubMed abstract 8626726
4  PubMed abstract 7499240
5  PubMed abstract 8621021
6  PubMed abstract 15489334
7  PubMed abstract 10428856
8  PubMed abstract 9166907
9  PubMed abstract 9144295
10  PubMed abstract 9500540
Domain NameLeptin  
Hormone NameLeptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
ReceptorP48357   Detail in HMRbase   
O95214   Detail in HMRbase   
O15243   Detail in HMRbase   
A8K2E3   Detail in HMRbase   
Q6FHL5   Detail in HMRbase   
Q6FHL7   Detail in HMRbase   
Gene ID3952      
PDB ID1AX8      
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