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Fatty acid amide represents a growing family of bioactive lipids with diverse cellular and biophysical effects. Member of this molecular family include oleamide, a sleep inducing lipid and an andamide, an endogenous ligand for the brain CB1 cannabinoids receptor.Because of therapeutic potential of inhibiting FAAH especially for the treatment of pain inflammation or sleep disorder and with emerging corners surrounding alternative target of cyclooxygenase 2 (COX2) inhibitors, there has been an increasing interest in development of potent inhibitors of this enzyme. FAAH is the only relevant target responsible for in vivo analgesic effect.For the purpose of predicting binding affinity of ketoxazole derivatives against Fatty Acid Amide Hydrolase (FAAH), we have developed this webserver. |
