1HDM	Immune System	date	Sep 09, 1998
title	Histocompatibility Antigen Hla-Dm
authors	L.Mosyak, D.M.Zaller, D.C.Wiley
compound		source
Molecule: Class II Histocompatibility Antigen, M Alpha Chain; Chain: A Fragment: Extracellular Domains Synonym: Ring6, Hla-Dma Engineered: Yes Biological_unit: Heterodimer		Organism_scientific: Homo Sapiens Organism_common: Human Cell: B-Lymphocyte Expression_system: Drosophila Hydei Other_details: Drosophila S2 Insect Cells
Molecule: Class II Histocompatibility Antigen, M Beta Chain; Chain: B Fragment: Extracellular Domains Synonym: Ring7, Hla-Dmb Engineered: Yes Biological_unit: Heterodimer		Organism_scientific: Homo Sapiens Organism_common: Human Cell: B-Lymphocyte Expression_system: Drosophila Hydei Other_details: Drosophila S2 Insect Cells
symmetry	Space Group: C 2 2 21	R_factor	0.197
crystal cell	length a length b length c angle alpha angle beta angle gamma 95.390 109.930 105.120 90.00 90.00 90.00
method	X-Ray Diffraction	resolution	2.50 Å
note	1HDM is a representative structure
similarity	Belongs to the MHC_II_beta family.
subunit	Heterodimer of m alpha and beta chains.
subcellular loc.	Extracellular.
genes	DMB, HLA-DMB, RING7 (H. sapiens)
function	Plays a critical role in catalyzing the release of class ii hla-associated invariant chain-derived peptides (clip) from newly synthesized class ii hla molecules and freeing the peptide binding site for acquisition of antigenic peptides.

Data retrieval

Asymmetric unit, PDB entry: [header only] [complete with coordinates] (73 Kb) [Save to disk] CSU: Contacts of Structural Units for 1HDM Likely Quarternary Molecular Structure file(s) for 1HDM Retrieve 1HDM in mmCIF format [Save to disk]

View 1HDM in 3D

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Visual 3D analysis of 1HDM

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Structure-derived information

Dipole moment, from Dipole Server at Weizmann Institute Classification of representative domains in scop (Structural Classification of Proteins)     - Domain d1hdma2, region A:13-93 [rasmolscript] [script source]     - Domain d1hdma1, region A:94-196 [rasmolscript] [script source]     - Domain d1hdmb2, region B:3-87 [rasmolscript] [script source]     - Domain d1hdmb1, region B:88-185 [rasmolscript] [script source] Fold representative 1hdm from FSSP and Dali (Families of Structurally Similar Proteins) Class (fold), Architecture (subfold), Topology, Homologous superfamily: CATH Summaries and structural analyses of PDB data files: PDBSum

Sequence-derived information

View one-letter amino acid or nucleotide sequence for each chain: [1hdm_A] [1hdm_B] SWISS-PROT database: [RNG7_HUMAN] Domain organization of [RNG7_HUMAN] by SWISSPFAM Domain found in 1HDM: [IGc1 ] by SMART Conserved protein region description, domain view and alignment from family MHC_II_beta (PF00969) of Pfam. Alignments of the sequence of 1HDM with the sequences similar proteins can be viewed for classification [RNG7_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list. A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [RNG7_HUMAN] at ProtoMap. Click on the Cluster number.

Other resources with information on 1HDM

InterPro: IPR003006 , IPR003597 , IPR000353 PDBREPORT (protein verification by WHAT_CHECK procedures) MMDB (Entrez's Structure Database)

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