Epitopes from Single antigens


This page displays the number of epitopes pertaining to a single antigen (Gene ID) with selected filters.




Number of ctl assays for antigen accession number 449065994 from the mycobacterial M_bovis_BCG_str_Korea strain



ID Peptide Position B cell epitope MHC I alleles MHC I alleles (number) HLA I alleles HLA I alleles (number) MHC II alleles MHC II alleles (number) IFN inducers IL4 inducers
SEC139282KVQVSGWRF8NoHLA-A3,HLA-A*3101,HLA-B*0702,HLA-B*2702,HLA-B*3501,HLA-B*5801,HLA-B62,MHC-Ld8HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-B*290210 0NoYes
SEC139283VQVSGWRFL9NoHLA-A*0201,HLA-A*0205,HLA-A2.1,HLA-B*2702,HLA-B*2705,HLA-B*3701,HLA-B*3902,HLA-B*51,HLA-B*5201,HLA-B*5301,HLA-B60,HLA-B62,HLA-B7,HLA-Cw*0301,MHC-Db,MHC-Db revised,MHC-Kd17HLA-B27,HLA-B*3501,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0112DRB1_0701,DRB1_0703 2NoYes
SEC139284QVSGWRFLL10NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-A2.1,HLA-A3,HLA-B*3701,HLA-B*3801,HLA-B*3902,HLA-B7,MHC-Db revised10HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139285VSGWRFLLR11NoHLA-A1,HLA-A20 Cattle,HLA-A*3302,HLA-A68.14HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139286SGWRFLLRR12NoHLA-A*3101,HLA-A*33022HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139287GWRFLLRRL13NoHLA-B7,HLA-Cw*0401,HLA-Cw*0602,MHC-Kd4HLA-A2,HLA-B*3501,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0112 0YesYes
SEC139289RFLLRRLEH15No0HLA-B*3501,HLA-B*5102,HLA-B*5103,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*680213 0YesYes
SEC139293RRLEHAIVR19NoHLA-A20 Cattle,HLA-A*3101,HLA-B*2702,HLA-B*27054HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139294RLEHAIVRR20NoHLA-A1,HLA-A*1101,HLA-A20 Cattle,HLA-A3,HLA-A*3101,HLA-A*3302,HLA-A68.1,HLA-B*27058HLA-A24,HLA-A*0301,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0YesYes
SEC139297HAIVRRDTR23NoHLA-A20 Cattle,HLA-A*3101,HLA-A*3302,HLA-A68.14HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139298AIVRRDTRM24NoHLA-A2,HLA-B14,HLA-B*35013HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139299IVRRDTRMF25NoHLA-B*3501,HLA-B*51,HLA-B623HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019DRB1_0402,DRB1_0801,DRB1_0802,DRB1_0804,DRB1_0806,DRB1_0813,DRB1_0817,DRB1_1102,DRB1_1114,DRB1_1120,DRB1_1121,DRB1_1128,DRB1_1301,DRB1_1302,DRB1_1304,DRB1_1305,DRB1_1322,DRB1_1323,DRB1_1327,DRB1_1328 20NoNo
SEC139306MFDDPLQFY32YesHLA-A1,HLA-B*51,HLA-Cw*0401,HLA-Cw*07024HLA-A1,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110 0NoNo
SEC139312QFYSRSIAL38NoHLA-A2.1,HLA-A24,HLA-B14,HLA-B*3801,HLA-B*3902,HLA-B*51,HLA-B*5401,HLA-Cw*0301,HLA-Cw*0401,MHC-Dd,MHC-Kb,MHC-Kd12HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoYes
SEC139315SRSIALGIV41NoHLA-B14,HLA-B*2702,HLA-B*2705,HLA-B*39014HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139316RSIALGIVV42NoHLA-B*0702,HLA-B*3501,HLA-B*5201,HLA-B*5801,HLA-B61,MHC-Ld6HLA-B*5301,HLA-B*51,HLA-B*0702,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*3301,HLA-A*680114 0NoNo
SEC139317SIALGIVVA43No0HLA-B*5401,HLA-B*51,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0NoNo
SEC139318IALGIVVAV44NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5301,HLA-B*5401,HLA-B*5801,HLA-B61,HLA-Cw*060212HLA-A*0301,HLA-B8,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111DRB1_0301,DRB1_0306,DRB1_0307,DRB1_0308,DRB1_0311,DRB1_1107 6NoNo
SEC139319ALGIVVAVL45NoHLA-A*0201,HLA-A*0205,HLA-A2.1,HLA-A3,HLA-B*2705,HLA-B*3701,HLA-B*3902,HLA-B62,HLA-B7,HLA-Cw*0401,HLA-Cw*070211HLA-A*0203,HLA-A3,HLA-A*0301,HLA-A2.1,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0114 0NoNo
SEC139321GIVVAVLIL47NoHLA-A*0205,HLA-A2,HLA-A3,HLA-B14,HLA-B*3901,HLA-B*3902,HLA-B7,HLA-Cw*0301,HLA-Cw*0401,MHC-Db,MHC-Kd11HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139325AVLILAGAA51NoHLA-A*0205,HLA-A68.12HLA-A2,HLA-B*51,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0NoNo
SEC139331GAALLAYFK57NoHLA-A*1101,HLA-A3,HLA-A68.13HLA-A2,HLA-A*0202,HLA-A*2402,HLA-A2.1,HLA-B*3501,HLA-B*5301,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0115 0NoYes
SEC139346GTSLFTDRA72NoHLA-B*58011HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*680210 0NoNo
SEC139350FTDRATNQL76YesHLA-B*3801,HLA-B*3901,HLA-B*3902,HLA-B*51,HLA-B*5301,HLA-B*5401,HLA-B*5801,HLA-B60,HLA-Cw*04019HLA-A2,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110 0YesNo
SEC139352DRATNQLYV78YesHLA-B14,HLA-B*2702,HLA-B*2705,HLA-B*5301,MHC-Db5HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*330110 0YesNo
SEC139354ATNQLYVLL80NoHLA-A2,HLA-A24,HLA-B*3701,HLA-B*3902,HLA-B*5801,HLA-B60,HLA-B7,HLA-Cw*0301,HLA-Cw*0602,MHC-Kb10HLA-A*0205,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0111 0NoNo
SEC139364GQLHPVYNL90NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-A3,HLA-A*3101,HLA-B14,HLA-B*2702,HLA-B*2705,HLA-B*3901,HLA-B*3902,HLA-B40,HLA-B60,HLA-B62,HLA-B7,HLA-Cw*0301,HLA-Cw*0401,MHC-Db revised,MHC-Kd18HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoYes
SEC139369VYNLTSARL95NoHLA-A24,HLA-B*3801,HLA-B*3902,HLA-B*51,HLA-Cw*0401,MHC-Kd6HLA-A24,HLA-B*3501,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111DRB1_0101,DRB1_0102,DRB1_0404,DRB1_0405,DRB1_0408,DRB1_0410,DRB1_0423 7NoYes
SEC139402VGIPGAPYA128NoHLA-B40,HLA-B*4403,HLA-B*51,HLA-B*53014HLA-B*51,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110 0YesYes
SEC139422TLCDTVARA148NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-A3,HLA-B625HLA-A1,HLA-A*0201,HLA-A*0301,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0112 0YesYes
SEC139428ARADSTSPV154YesHLA-B14,HLA-B*2702,HLA-B*2705,HLA-B*39014HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*330110 0NoYes
SEC139429RADSTSPVV155NoHLA-A2.1,HLA-B*0702,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5201,HLA-B*5801,HLA-B618HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139433TSPVVQTAV159NoHLA-B*5103,HLA-B*5801,MHC-Dd,MHC-Ld4HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*680210 0NoNo
SEC139464SYQGETWIV190NoHLA-A24,HLA-B*5201,HLA-Cw*0401,MHC-Kd4HLA-A24,HLA-A*2402,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0NoYes
SEC139467GETWIVTTK193NoHLA-A*1101,HLA-A3,HLA-B*2705,HLA-B*44034HLA-A24,HLA-A*2402,HLA-B*5301,HLA-B8,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0113 0NoYes
SEC139479AIDLTDRAL205YesHLA-B*3801,HLA-B*3902,HLA-Cw*04013HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0110 0NoYes
SEC139490SMGIPVTAR216NoHLA-A20 Cattle,HLA-A3,HLA-A*3101,HLA-A*3302,HLA-A68.1,HLA-B*27056HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoYes
SEC139498RPTPISEGM224YesHLA-B*0702,HLA-B*3501,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5301,HLA-B*5401,HLA-B*5801,HLA-B7,HLA-Cw*0401,MHC-Ld12HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139502ISEGMFNAL228NoHLA-A1,HLA-A24,HLA-B*3801,HLA-B*3901,HLA-B*3902,HLA-B*51,HLA-B*5801,HLA-B60,HLA-Cw*0301,HLA-Cw*0602,MHC-Kb11HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0110 0NoYes
SEC139510LPDMGPWQL236NoHLA-B*3501,HLA-B*3801,HLA-B*3901,HLA-B*3902,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5301,HLA-B*5401,HLA-B60,HLA-B7,HLA-Cw*0401,MHC-Ld14HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoYes
SEC139545HTDKGPQYY271NoHLA-A1,HLA-B*4403,HLA-B*5801,HLA-Cw*07024HLA-A1,HLA-A3,HLA-B*51,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0112 0NoYes
SEC139555VLPDGIAQV281NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-A2.1,HLA-B*51,HLA-B*5103,HLA-B62,MHC-Dd8HLA-B*0702,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110DRB1_0301,DRB1_0305,DRB1_0306,DRB1_0307,DRB1_0308,DRB1_0309,DRB1_0311,DRB1_1107 8NoNo
SEC139562QVNATTAAA288No0HLA-A2,HLA-B*5401,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0YesYes
SEC139578GLVAPPAMV304NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-A2.1,HLA-A3,HLA-B626HLA-A*0203,HLA-A2.1,HLA-B*5301,HLA-B*5401,HLA-B*51,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0114 0NoYes
SEC139585MVPSLVVRI311NoHLA-A*0201,HLA-A*0205,HLA-B*51,HLA-B*5102,HLA-B*5301,HLA-Cw*0602,MHC-Dd,MHC-Kk8HLA-B*51,HLA-B8,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111DRB1_0101,DRB1_0102,DRB1_0301,DRB1_0305,DRB1_0306,DRB1_0307,DRB1_0308,DRB1_0309,DRB1_0311,DRB1_0401,DRB1_0402,DRB1_0404,DRB1_0408,DRB1_0421,DRB1_0423,DRB1_0426,DRB1_0701,DRB1_0703,DRB1_1102,DRB1_1104,DRB1_1106,DRB1_1107,DRB1_1114,DRB1_1120,DRB1_1121,DRB1_1301,DRB1_1302,DRB1_1304,DRB1_1311,DRB1_1322,DRB1_1323,DRB1_1327,DRB1_1328 33NoNo
SEC139586VPSLVVRIA312NoHLA-B*0702,HLA-B*3501,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5201,HLA-B*5301,HLA-B*5401,MHC-Ld10HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019DRB1_1102,DRB1_1114,DRB1_1121,DRB1_1322,DRB1_1323 5NoNo
SEC139588SLVVRIAER314NoHLA-A20 Cattle,HLA-A3,HLA-A*3101,HLA-A*3302,HLA-A68.15HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0NoNo
SEC139640HLPISPSAM366NoHLA-B*0702,HLA-B*3501,HLA-B62,MHC-Dd,MHC-Kb5HLA-A24,HLA-A*0301,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0NoYes
SEC139647AMNMGIKQI373NoHLA-A*0201,HLA-A*0205,HLA-A2.1,HLA-A3,HLA-B*5101,MHC-Db revised,MHC-Kk7HLA-A3,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110 0NoYes
SEC139653KQIHGTATV379NoHLA-A*0201,HLA-A*0205,HLA-A2,HLA-B*0702,HLA-B*2702,HLA-B*2705,HLA-B*5102,HLA-B*5201,HLA-B629HLA-B14,HLA-B*5301,HLA-B*5401,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0112 0NoYes
SEC139655IHGTATVYL381NoHLA-B*3801,HLA-B*3901,HLA-B*3902,HLA-B*51,HLA-B*5301,MHC-Kb6HLA-A2,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0110DRB1_0401,DRB1_0421,DRB1_0426,DRB1_0701,DRB1_0703 5YesYes
SEC139663LDGGKFVAL389NoHLA-B*3701,HLA-B40,HLA-B*51,HLA-B*5301,HLA-B60,HLA-Cw*0301,MHC-Dd,MHC-Kb8HLA-B*0702,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0111 0NoYes
SEC139677RYTESMYYI403NoHLA-A24,HLA-B*0702,HLA-Cw*0401,MHC-Kd4HLA-A*1101,HLA-A11,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-A*330112 0NoYes
SEC139684YIDPQGVRY410NoHLA-A1,HLA-A3,HLA-B*51,HLA-B*5301,HLA-B*5401,HLA-B62,HLA-Cw*07027HLA-A1,HLA-B14,HLA-B8,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*01,HLA-B*270313 0NoYes
SEC139686DPQGVRYGV412NoHLA-B*0702,HLA-B*3501,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5201,HLA-B*5301,HLA-B*5401,HLA-B61,HLA-B7,HLA-Cw*0401,MHC-Ld13HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*019 0YesYes
SEC139693GVPNAETAK419NoHLA-A*1101,HLA-A3,HLA-A68.13HLA-A24,HLA-A*2402,HLA-B*0702,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0113 0NoNo
SEC139710NAPWEIVRL436NoHLA-B*3501,HLA-B*3902,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5801,HLA-B60,HLA-B7,HLA-Cw*0401,MHC-Db,MHC-Dd,MHC-Kb12HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,HLA-B35,Mamu-A*0110 0YesYes
SEC139711APWEIVRLL437NoHLA-A24,HLA-B*0702,HLA-B14,HLA-B*3501,HLA-B*3701,HLA-B*3801,HLA-B*3901,HLA-B*3902,HLA-B40,HLA-B*51,HLA-B*5101,HLA-B*5102,HLA-B*5103,HLA-B*5201,HLA-B*5301,HLA-B*5401,HLA-B60,HLA-B7,HLA-B8,HLA-Cw*0401,HLA-Cw*0602,HLA-Cw*0702,MHC-Ld23HLA-A*0301,HLA-B8,HLA-Cw*0401,H2-Db,H2-Dd,H2-Kb,H2-Kd,H2-Ld,HLA-G,H-2Qa,Mamu-A*0111 0YesYes