| PolysacDB ID | 2050 |
| Carbohydrate Name | O-polysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Pseudomonas aeruginosa (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
|
| BCSDB Structure | N/A |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | HMab 2-8AH79 |
| Antibody type and class | IgM |
| Assay System | ELISA, immunoblotting, immunofluorescence, opsonophagocytic assays and mouse protection studies |
| Cross-reactivity | "This Mab reacts with Fisher immunotype (IT) 1, 3, 4, and 6" |
| Proposed epitopes | N/A |
| IEDB Epitope | 76837 |
| Proposed Utility | This Mab promoted the uptake and killing of IT-3 and IT-4 bacteria, but not IT-1 or IT-6 organisms, by human polymorphonuclear leukocytes. The passive transfer of HMAb 2-8AH79 to mice afforded significant protection only against a challenge with IT-3 and IT-4 bacteria |
| Curator ID | AA + AS |
| Date of Curation | 30-12-2010
|
| References | PMC259916 |