PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us
Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 3

Entry No. - 1   [TOP]
PolysacDB ID2649
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG3
Antibody type and classMab S5
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


Entry No. - 2   [TOP]
PolysacDB ID2650
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG3
Antibody type and classMab S8
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab enhanced CL responses of human PMNs to the organism and killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


Entry No. - 3   [TOP]
PolysacDB ID2653
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeActinobacillus pleuropneumoniae serotype 7   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodies0.2% formalinized whole cell antigens
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgG3
Antibody type and classMabs 7.1.11C8E3
Assay SystemDot-ELISA, ELISA-inhibition test
Cross-reactivityThis mab reacted only with reference strains of A. pleuropneumoniae serotypes 7
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis mab was shown to be suitable for serotyping since they detected 100% of serotype 7 strains
Curator IDAA + AS
Date of Curation26-01-2012
References10223326


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036