| PolysacDB ID | 1215 |
| Carbohydrate Name | Smooth Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Brucella melitensis strain B115 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The S-LPS of smooth-type Brucella spp. contains two distinct antigenic determinants designated A and M
|
| BCSDB Structure | N/A |
| Proposed functions | LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin |
| Antigenic Nature used to produce antibodies | Whole cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 04A05 |
| Antibody type and class | IgG3 |
| Assay System | ELISA and immunoblotting |
| Cross-reactivity | This antibody was specific to a common epitope on A and M polysaccharides. But was more reactive towards M dominant strain B. melitensis 16M.This Mab cross-reacted with O-PS of B. abortus 99 but did not bind to R-LPS of B. melitensis B11; also did not cross-react with Y. enterocolitica0:9 LPS |
| Proposed epitopes | Both α1-->2 and α1-->3 linkages seem to be an important part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This mAb may be particularly useful for typingsmooth Brucella strains |
| Curator ID | AA + AS |
| Date of Curation | 12-03-2010
|
| References | 1382111 |