PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1971
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeStreptococcus pneumoniae serotype 6B   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P-
BCSDB Structure5205
Proposed functionsN/A
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameTetanus toxoid
Conjugation MethodThe oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid
AntibodiesMab 10H8
Antibody type and classIgG1
Assay SystemEnzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay
Cross-reactivityThis Mab reacted with polysaccharides from 11A, 19F and 23F strain but did not recognize type 6A polysaccharide
Proposed epitopesDisaccharide rhamnose-(1-->4)-ribitol phosphate residues seemed to be the part of the epitope
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation08-12-2010
ReferencesPMC95896


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