PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1018
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeCryptococcus neoformans   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
BCSDB Structure113471
Proposed functionsThe capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodiesCryptococci cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesMab 11E2
Antibody type and classIgM
Assay SystemELISA
Cross-reactivityThis antibody was specific to D serotype and cross-reacted with GH strain
Proposed epitopesN\A
IEDB EpitopeN/A
Proposed UtilityThis antibody was shown to bind to cryptococcal capsule
Curator IDAA + AS
Date of Curation05-01-2010
ReferencesPMC2118886


Entry No. - 2   [TOP]
PolysacDB ID1286
Carbohydrate NamePhosphomannan protein complex   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeCandida albicans NIH B-792   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesHeat-killed yeast-form cells of Candida albicans NIH B-792 strain
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 11E2
Antibody type and classIgM
Assay SystemN/A
Cross-reactivityThis antibody cross-reacted with NIH A-207 (serotype A) and J-1012 [serotype A] and C. tropicalis IFO 0587
Proposed epitopesThe epitope was proposed to contain β-1,2-linked oligomannosyl residues
IEDB EpitopeN/A
Proposed UtilityAntibodies to β- 1,2-linked oligomannosyl residues can be used as the serodiagnostic agent for detecting the C. albicans antigen(s) in sera and tissues of mammals with candidiasis.
Curator IDAA + AS
Date of Curation15-05-2010
References3280163


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