PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1794
Carbohydrate NameN-propionylated group B meningococcal polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeNeisseria meningitidis   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt consists of a homopolymer of α(2-->8)-linked sialic acid residues
BCSDB StructureN/A
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameTetanus toxoid
Conjugation MethodN-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37°C for 5 days
AntibodiesMab 12C5
Antibody type and classIgG2b
Assay SystemELISA, bactericidal assays
Cross-reactivityN/A
Proposed epitopesThe epitope was located only on extended helical segments of the polysaccharide
IEDB EpitopeN/A
Proposed UtilityThis Mab had bactericidal activity
Curator IDAA + AS
Date of Curation02-11-2010
ReferencesPMC2196336


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036