PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2556
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae serogroup O139   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesWhole cell lysates
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 15F5-H5
Antibody type and classIgG2b
Assay SystemDot-blot ELISA, immunoblotting, ELISA
Cross-reactivityThis Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139
Curator IDAA + AS
Date of Curation25-06-2011
References9817879


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