PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1391
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella minnesota R595   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesAcid-treated and lipid A-coated S. minnesota R596
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 1C9
Antibody type and classIgM
Assay SystemELISA, immunoblotting and RIA
Cross-reactivityThis antibody cross-reacted with E. coli J5, E. Coli O111:B4, R595, K. pneumoniae, S. marcescens, and P. Aeruginosa but did not cross-react with Staphylococcus aureus, S. minnesota and Staphylococcus faecalis
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation07-07-2010
ReferencesPMC260436


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