PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1492
Carbohydrate NameHeptasaccharide motif (M2) of Glucurunoxylomannan   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeCryptococcus neoformans Serotype D [strain 24067]   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe heptasaccharide consists of two M2 triad repeats and mannose residue. The M2 repeat was selected because it is commonly found in GXM of serotype A strain
BCSDB StructureN/A
Proposed functionsGlucurunoxylomannan is an antiphagocytic determinant ; an important virulence factor
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameHuman serum albumin
Conjugation MethodN/A
AntibodiesMab 1D6
Antibody type and classIgM
Assay SystemImmunofluorescence and phagocytosis assays
Cross-reactivityThis antibody cross-reacted with Serotype D
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation03-08-2010
References19464529


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