PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1877
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeNeisseria gonorrhoeae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureGonococcal lipopolysaccharide (LPS) is a complex of at least three major antigenic determinants. The ceramide part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/. The core oligosaccharide part consists of the following residues : α-D-GlcpNAc-(1-->2)-L-gro [branched to β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)] -α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-Kdo. The other part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-GlcpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)-L-gro [branched to α-D-GlcpNAc-(1-->2)-L-gro-α-D-manHepp-(1-->3)] -α-D-manHepp-(1-->5)-Kdo
BCSDB Structure134700
Proposed functionsIt is an important virulence factor
Antigenic Nature used to produce antibodiesGonococcal outer membranes
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 2C7
Antibody type and classIgG3
Assay SystemELISA, immunoblotting
Cross-reactivityThis Mab was broadly cross-reactive among Neisseria gonorrhoeae strains except among WR213, F62, 8038-5, DAV, 6611-33, GC33 and WR302
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation20-11-2010
ReferencesPMC260117


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