| PolysacDB ID | 2602 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Cryptococcus neoformans Serotype D (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
|
| BCSDB Structure | 136943 |
| Proposed functions | The capsular polysaccharide is an important virulence factor |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Sheep erythrocytes |
| Conjugation Method | The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature |
| Antibodies | Mab 386 |
| Antibody type and class | N/A |
| Assay System | ELISA and Immunodiffusion |
| Cross-reactivity | This antibody has a highly variable cross-reactivity. It cross reacts with most strains of Serotype A and D. It cross reacts with only one strain of serotype B and 2 strains of serotype C. does not show a reaction with ELISA |
| Proposed epitopes | Since Mab 386 does not show any positive results with ELISA, it is suggested that binding of polysaccharides to plates coated with poly-L-lysine altered the carboxyl residues that may form part of an epitope recognized by the antibody |
| IEDB Epitope | N/A |
| Proposed Utility | Used to differentiate various strains of all serotypes |
| Curator ID | AA + AS |
| Date of Curation | 15-07-2011
|
| References | 2476401 |