PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1050
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeEscherichia coli strain J5 (chemotype Rc)   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core oligosaccharide part of the LPS consists of the following residues : α-D-Glcp(1-->2)α-D-Glcp(1-->2)α-D-Glcp [branched to α-D-GlcpNAc(1-->3)] (1-->3)α-L-D-man-Hepp [branched to α-D-GlcpNAc(1-->7)α-L-D-man-Hepp(1-->7)] and [branched to a phosphate group] (1-->3)α-L-D-man-Hepp [branched to α-Kdop(2-->4)α-Kdop(2-->4)α-Kdop(2-6)Subst] and [branched to a phosphate group](1-->5)
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 4
Antibody type and classIgG2a
Assay SystemELISA, Limulus assay, invivo protection assay
Cross-reactivityThis antibody ross-reacted with Salmonella minnesota strain R5
Proposed epitopesTerminal glucose residues
IEDB EpitopeN/A
Proposed UtilityN/A
Curator IDAA + AS
Date of Curation16-01-2010
References2455054


Entry No. - 2   [TOP]
PolysacDB ID1485
Carbohydrate NameUnknown carbohydrate   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeHistoplasma capsulatum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesDisrupted yeast cell homogenate of Histoplasma capsulatum
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 4
Antibody type and classIgG3
Assay SystemELISA, immunoblotting and Solid-phase radioimmunoassay
Cross-reactivityMAb 4 cross-reacted with B. dermatitidis, C. albicans, Coccidioides immitis, Aspergillus fumigatus, and Mycobacterium tuberculosis
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityMAbs may prove useful in the development of more specific immunodiagnostic tests for histoplasmosis
Curator IDAA + AS
Date of Curation31-07-2010
ReferencesPMC313195


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