| PolysacDB ID | 1043 |
| Carbohydrate Name | Galactomannan (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Aspergillus fumigatus (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Galactomannan is composed of a branched core containing α(1-->2)- and α(1-->6)-linked mannose, with β(1-->5)galactofuranose and/or β(1-->4)galactopyranose moieties linked linearly in side chains terminated by galactofuranose nonreducing end units
|
| BCSDB Structure | N/A |
| Proposed functions | Galactomannan is a major cell wall component in Aspergillusspecies and can also be secreted into the medium as a component of the exoantigen. The galactomannan is immunogenic and polyclonal antibodies against it have been used in antigen detection for the diagnosis of invasive aspergillosis, and in the detection of fungal contamination in foodstuffs |
| Antigenic Nature used to produce antibodies | Cold alkali extract of mycelium |
| Carrier Name | N/A |
| Conjugation Method | N/A |
| Antibodies | Mab 40 |
| Antibody type and class | IgM |
| Assay System | Indirect Enzyme Immunoassay, immunofluorescence, Preciptin assay |
| Cross-reactivity | This antibody was cross-reactive with C.albicans |
| Proposed epitopes | Mannopyranosyl side chain |
| IEDB Epitope | N/A |
| Proposed Utility | This antibody can be used to detect circulating antigen in the serum of patients with invasive aspergillosis by ELISA inhibition. |
| Curator ID | AA + AS |
| Date of Curation | 13-01-2010
|
| References | PMC258783 |