PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1023
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeCryptococcus neoformans   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
BCSDB Structure113471
Proposed functionsThe capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodiesCryptococci cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesMab 4H3
Antibody type and classIgG3
Assay SystemELISA
Cross-reactivityThis antibody was specific to D serotype and cross-reacted with GH strain
Proposed epitopesN\A
IEDB EpitopeN/A
Proposed UtilityThis antibody was shown to bind to cryptococcal capsule
Curator IDAA + AS
Date of Curation07-01-2010
ReferencesPMC2118886


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