PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2179
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella typhimurium   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-
BCSDB Structure6380
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 5A5
Antibody type and classIgM
Assay SystemELISA, immunoblotting, dot blot assay, immunoelectron microscopy
Cross-reactivityThis Mab reacted with S. typhimurium (LPS O:1, 4, 5, and 12) while failing to recognize S. typhimurium var. copenhagen (LPS O:1, 4, and 12). It reacted equally with live and heat-attenuated Salmonella B serovars containing LPS O-5 antigen
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used to discriminate between S. typhimurium and S. typhimurium var. copenhagen
Curator IDAA + AS
Date of Curation23-02-2011
ReferencesPMC167767


Bioinformatics Centre, Institute of Microbial Technology, Sec - 39A, Chandigarh, India - 160036